| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 |
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| Ligand | BDBM50355642 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_776872 (CHEMBL1914006) |
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| IC50 | 25000±n/a nM |
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| Citation |  Sheriff, S; Beno, BR; Zhai, W; Kostich, WA; McDonnell, PA; Kish, K; Goldfarb, V; Gao, M; Kiefer, SE; Yanchunas, J; Huang, Y; Shi, S; Zhu, S; Dzierba, C; Bronson, J; Macor, JE; Appiah, KK; Westphal, RS; O'Connell, J; Gerritz, SW Small molecule receptor protein tyrosine phosphatase¿ (RPTP¿) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop. J Med Chem54:6548-62 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 1 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 1 |
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| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 49963.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant GST-fusion PTP1B (1-435). |
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| Residue: | 435 |
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| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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| BDBM50355642 |
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| n/a |
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| Name | BDBM50355642 |
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| Synonyms: | CHEMBL1910888 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14Cl2N2O3S3 |
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| Mol. Mass. | 473.416 |
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| SMILES | Nc1cccc(c1)S(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1 |
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| Structure | 
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