Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50356344 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_775369 (CHEMBL1912854) | ||
IC50 | 7±n/a nM | ||
Citation | Ye, XY; Chen, SY; Nayeem, A; Golla, R; Seethala, R; Wang, M; Harper, T; Sleczka, BG; Li, YX; He, B; Kirby, M; Gordon, DA; Robl, JA Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1). Bioorg Med Chem Lett21:6699-704 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50356344 | |||
n/a | |||
Name | BDBM50356344 | ||
Synonyms: | CHEMBL1911405 | ||
Type | Small organic molecule | ||
Emp. Form. | C18H21FO2 | ||
Mol. Mass. | 288.3565 | ||
SMILES | OC(=O)CC1(C2CC3CC(C2)CC1C3)c1cccc(F)c1 |TLB:13:12:10:6.7.8,3:4:6.13.7:11.9.10,THB:13:7:4.12.11:10,8:7:4:11.9.10,8:9:4:6.13.7,3:4:10:6.7.8,14:4:6.13.7:11.9.10,(5.96,-24.19,;7.29,-24.96,;8.63,-24.19,;7.29,-26.5,;8.63,-27.28,;9.83,-26,;11.16,-26.49,;12.55,-26.15,;12.56,-24.62,;11.17,-24.04,;9.82,-24.52,;10.13,-25.28,;10.13,-26.86,;11.54,-27.43,;7.89,-28.63,;8.69,-29.94,;7.95,-31.29,;6.4,-31.33,;5.61,-30.01,;4.06,-30.04,;6.35,-28.66,)| | ||
Structure |