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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Androgen receptor | ||
| Ligand | BDBM50356994 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_788156 (CHEMBL1919237) | ||
| IC50 | 136±n/a nM | ||
| Citation |  Guo, C; Linton, A; Kephart, S; Ornelas, M; Pairish, M; Gonzalez, J; Greasley, S; Nagata, A; Burke, BJ; Edwards, M; Hosea, N; Kang, P; Hu, W; Engebretsen, J; Briere, D; Shi, M; Gukasyan, H; Richardson, P; Dack, K; Underwood, T; Johnson, P; Morell, A; Felstead, R; Kuruma, H; Matsimoto, H; Zoubeidi, A; Gleave, M; Los, G; Fanjul, AN Discovery of aryloxy tetramethylcyclobutanes as novel androgen receptor antagonists. J Med Chem54:7693-704 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Androgen receptor | |||
| Name: | Androgen receptor | ||
| Synonyms: | ANDR_HUMAN | AR | Androgen Receptor | Androgen receptor (AR) | Androgen receptor/Baculoviral IAP repeat-containing protein 2 | DHTR | Dihydrotestosterone receptor | NR3C4 | Nuclear receptor subfamily 3 group C member 4 | ||
| Type: | Receptor | ||
| Mol. Mass.: | 99185.27 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | CHO cells were stably transfected with human AR gene. | ||
| Residue: | 920 | ||
| Sequence: |
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| BDBM50356994 | |||
| n/a | |||
| Name | BDBM50356994 | ||
| Synonyms: | CHEMBL1916250 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H25ClN4O3 | ||
| Mol. Mass. | 416.901 | ||
| SMILES | CC1(C)[C@H](NC(=O)c2ccn(CCO)n2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1 |r,wU:3.3,wD:18.20,(-6.58,-47.2,;-6.17,-45.72,;-7.67,-46.11,;-4.63,-45.72,;-3.28,-46.46,;-3.25,-48,;-4.57,-48.8,;-1.9,-48.75,;-1.88,-50.28,;-.41,-50.74,;.48,-49.48,;2.02,-49.47,;2.8,-50.79,;4.34,-50.78,;-.44,-48.25,;-4.63,-44.18,;-4.24,-42.68,;-3.15,-44.57,;-6.17,-44.18,;-7.5,-43.4,;-7.49,-41.86,;-8.82,-41.1,;-8.82,-39.56,;-7.48,-38.79,;-7.48,-37.25,;-7.47,-35.72,;-6.15,-39.56,;-4.82,-38.8,;-6.16,-41.1,)| | ||
| Structure | 
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