| Reaction Details |
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 | Report a problem with these data |
| Target | Ephrin type-A receptor 8 |
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| Ligand | BDBM50357333 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_787379 (CHEMBL1919258) |
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| IC50 | 434±n/a nM |
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| Citation |  Kim, KH; Maderna, A; Schnute, ME; Hegen, M; Mohan, S; Miyashiro, J; Lin, L; Li, E; Keegan, S; Lussier, J; Wrocklage, C; Nickerson-Nutter, CL; Wittwer, AJ; Soutter, H; Caspers, N; Han, S; Kurumbail, R; Dunussi-Joannopoulos, K; Douhan, J; Wissner, A Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett21:6258-63 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ephrin type-A receptor 8 |
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| Name: | Ephrin type-A receptor 8 |
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| Synonyms: | EEK | EPHA8 | EPHA8_HUMAN | Ephrin receptor | Ephrin type-A receptor 8 | HEK3 | KIAA1459 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 111022.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774600 |
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| Residue: | 1005 |
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| Sequence: | MAPARGRLPPALWVVTAAAAAATCVSAARGEVNLLDTSTIHGDWGWLTYPAHGWDSINEV
DESFQPIHTYQVCNVMSPNQNNWLRTSWVPRDGARRVYAEIKFTLRDCNSMPGVLGTCKE
TFNLYYLESDRDLGASTQESQFLKIDTIAADESFTGADLGVRRLKLNTEVRSVGPLSKRG
FYLAFQDIGACLAILSLRIYYKKCPAMVRNLAAFSEAVTGADSSSLVEVRGQCVRHSEER
DTPKMYCSAEGEWLVPIGKCVCSAGYEERRDACVACELGFYKSAPGDQLCARCPPHSHSA
APAAQACHCDLSYYRAALDPPSSACTRPPSAPVNLISSVNGTSVTLEWAPPLDPGGRSDI
TYNAVCRRCPWALSRCEACGSGTRFVPQQTSLVQASLLVANLLAHMNYSFWIEAVNGVSD
LSPEPRRAAVVNITTNQAAPSQVVVIRQERAGQTSVSLLWQEPEQPNGIILEYEIKYYEK
DKEMQSYSTLKAVTTRATVSGLKPGTRYVFQVRARTSAGCGRFSQAMEVETGKPRPRYDT
RTIVWICLTLITGLVVLLLLLICKKRHCGYSKAFQDSDEEKMHYQNGQAPPPVFLPLHHP
PGKLPEPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQR
DVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGS
LDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFG
LSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYW
NMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPE
SLRATATVSRCPPPAFVRSCFDLRGGSGGGGGLTVGDWLDSIRMGRYRDHFAAGGYSSLG
MVLRMNAQDVRALGITLMGHQKKILGSIQTMRAQLTSTQGPRRHL
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| BDBM50357333 |
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| n/a |
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| Name | BDBM50357333 |
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| Synonyms: | CHEMBL1916891 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25FN6O |
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| Mol. Mass. | 432.4933 |
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| SMILES | CN(C)C\C=C\C(=O)N(C)c1cc2c(cc1F)nc(Nc1ccccc1C)c1cncn21 |
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| Structure | 
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