| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta |
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| Ligand | BDBM50362516 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_798474 (CHEMBL1944323) |
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| IC50 | 140±n/a nM |
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| Citation |  Li, B; Cociorva, OM; Nomanbhoy, T; Li, Q; Nakamura, K; Nomura, M; Okada, K; Yumoto, K; Liyanage, M; Zhang, MC; Aban, A; Szardenings, AK; Kozarich, JW; Kohno, Y; Shreder, KR 6-Position optimization of tricyclic 4-quinolone-based inhibitors of glycogen synthase kinase-3ß: discovery of nitrile derivatives with picomolar potency. Bioorg Med Chem Lett22:1005-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta |
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| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
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| Type: | Enzyme |
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| Mol. Mass.: | 46756.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49841 |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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| BDBM50362516 |
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| n/a |
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| Name | BDBM50362516 |
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| Synonyms: | CHEMBL1940984 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22FN7O3 |
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| Mol. Mass. | 415.4215 |
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| SMILES | C[C@H]1COc2c(NCCCn3ccnc3)c(F)c(N)c3c2n1cc(C(=N)NO)c3=O |r| |
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| Structure | 
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