| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member A1 |
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| Ligand | BDBM50363059 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_800762 (CHEMBL1948098) |
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| IC50 | 14000±n/a nM |
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| Citation |  Minehira, D; Takeda, D; Urata, H; Kato, A; Adachi, I; Wang, X; Matsuya, Y; Sugimoto, K; Takemura, M; Endo, S; Matsunaga, T; Hara, A; Koseki, J; Narukawa, K; Hirono, S; Toyooka, N Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-ß-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1. Bioorg Med Chem20:356-67 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member A1 |
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| Name: | Aldo-keto reductase family 1 member A1 |
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| Synonyms: | AK1A1_HUMAN | AKR1A1 | ALDR1 | ALR | Alcohol dehydrogenase [NADP+] | Aldehyde Reductase (ALR1) | Aldehyde reductase | Aldo-keto reductase family 1 member A1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 36574.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 325 |
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| Sequence: | MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL
KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER
GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP
AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK
YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV
PMLTVDGKRVPRDAGHPLYPFNDPY
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| BDBM50363059 |
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| n/a |
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| Name | BDBM50363059 |
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| Synonyms: | CHEMBL1946964 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17BrN2O2S |
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| Mol. Mass. | 429.33 |
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| SMILES | OC(=O)Cn1c2c(CCN(Cc3ccc(Br)cc3)C2=S)c2ccccc12 |
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| Structure | 
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