| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM50365240 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_808186 (CHEMBL1961098) |
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| IC50 | >100000±n/a nM |
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| Citation |  Coteron, JM; Marco, M; Esquivias, J; Deng, X; White, KL; White, J; Koltun, M; El Mazouni, F; Kokkonda, S; Katneni, K; Bhamidipati, R; Shackleford, DM; Angulo-Barturen, I; Ferrer, SB; Jiménez-Díaz, MB; Gamo, FJ; Goldsmith, EJ; Charman, WN; Bathurst, I; Floyd, D; Matthews, D; Burrows, JN; Rathod, PK; Charman, SA; Phillips, MA Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. J Med Chem54:5540-61 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 42881.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02127 |
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| Residue: | 395 |
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| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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| BDBM50365240 |
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| n/a |
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| Name | BDBM50365240 |
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| Synonyms: | CHEMBL1956272 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18F3N5 |
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| Mol. Mass. | 349.3535 |
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| SMILES | Cc1cc(Nc2ccc(cc2)C(F)(F)F)n2nc(nc2n1)C(C)(C)C |
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| Structure | 
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