| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuromedin-B receptor |
|---|
| Ligand | BDBM50071754 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_143206 (CHEMBL752222) |
|---|
| Ki | 6.3±n/a nM |
|---|
| Citation |  Eden, J; Hall, M; Higginbottom, M; Horwell, D; Howson, W; Hughes, J; Jordan, R; Lewthwaite, R; Martin, K; McKnight, A; Pinnock, R; Pritchard, M; Suman-Chauhan, N; Williams, S PD 165929 the first high affinity non-peptide neuromedin-B (NMB) receptor selective antagonist Bioorg Med Chem Lett6:2617-2622 (1996) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuromedin-B receptor |
|---|
| Name: | Neuromedin-B receptor |
|---|
| Synonyms: | Bombesin 1 | NMB-R | NMBR | NMBR_HUMAN | Neuromedin B | Neuromedin B receptor | Neuromedin-B receptor | Neuromedin-B-preferring bombesin receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 43447.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Bombesin 1 NMBR 0::P28336 |
|---|
| Residue: | 390 |
|---|
| Sequence: | MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLG
NIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIP
VIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAV
FSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLI
KSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSL
GHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAV
RMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
|
|
|
|---|
| BDBM50071754 |
|---|
| n/a |
|---|
| Name | BDBM50071754 |
|---|
| Synonyms: | (S)-2-[3-(2,6-Diisopropyl-phenyl)-ureido]-3-(1H-indol-3-yl)-2-methyl-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide | CHEMBL86828 | NMB | Xenopus NMB |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C37H47N5O2 |
|---|
| Mol. Mass. | 593.8014 |
|---|
| SMILES | CC(C)c1cccc(C(C)C)c1NC(=O)N[C@@](C)(Cc1c[nH]c2ccccc12)C(=O)NCC1(CCCCC1)c1ccccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
