| Reaction Details |
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 | Report a problem with these data |
| Target | Threonine--tRNA ligase 1, cytoplasmic |
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| Ligand | BDBM50366646 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_210571 |
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| IC50 | 15±n/a nM |
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| Citation |  Forrest, AK; Jarvest, RL; Mensah, LM; O'Hanlon, PJ; Pope, AJ; Sheppard, RJ Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases. Bioorg Med Chem Lett10:1871-4 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Threonine--tRNA ligase 1, cytoplasmic |
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| Name: | Threonine--tRNA ligase 1, cytoplasmic |
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| Synonyms: | SYTC_HUMAN | TARS | TARS1 | Threonyl-tRNA synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83435.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_935846 |
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| Residue: | 723 |
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| Sequence: | MFEEKASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPWPEYIYTRLEM
YNILKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIA
KVNNVVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIE
NGFYYDMYLEEGGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAMFKYNKFKCRIL
NEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTYWEGKADMETLQRIYGI
SFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFI
RSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMF
DHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCL
DFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFY
GPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERM
IAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNK
KIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAE
EEF
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| BDBM50366646 |
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| n/a |
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| Name | BDBM50366646 |
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| Synonyms: | CHEMBL1163068 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H21N7O8S |
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| Mol. Mass. | 447.424 |
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| SMILES | C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| |
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| Structure | 
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