| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-3 adrenergic receptor |
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| Ligand | BDBM50106810 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_39052 |
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| Ki | 11±n/a nM |
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| Citation |  Washburn, WN; Sher, PM; Poss, KM; Girotra, RN; McCann, PJ; Gavai, AV; Mikkilineni, AB; Mathur, A; Cheng, P; Dejneka, TC; Sun, CQ; Wang, TC; Harper, TW; Russell, AD; Slusarchyk, DA; Skwish, S; Allen, GT; Hillyer, DE; Frohlich, BH; Abboa-Offei, BE; Cap, M; Waldron, TL; George, RJ; Tesfamariam, B; Ciosek, CP; Ryono, D; Young, DA; Dickinson, KE; Seymour, AA; Arbeeny, CM; Gregg, RE Beta 3 agonists. Part 1: evolution from inception to BMS-194449. Bioorg Med Chem Lett11:3035-9 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-3 adrenergic receptor |
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| Name: | Beta-3 adrenergic receptor |
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| Synonyms: | ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 43534.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 408 |
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| Sequence: | MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
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| BDBM50106810 |
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| n/a |
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| Name | BDBM50106810 |
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| Synonyms: | CHEMBL317621 | N-(5-((R)-2-((R)-1-(3,4-dimethoxyphenyl)-2-phenylethylamino)-1-hydroxyethyl)-2-hydroxyphenyl)methanesulfonamide | N-(5-{2-[1-(3,4-Dimethoxy-phenyl)-2-phenyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-phenyl)-methanesulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30N2O6S |
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| Mol. Mass. | 486.581 |
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| SMILES | COc1ccc(cc1OC)[C@@H](Cc1ccccc1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 |
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| Structure | 
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