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TargetBeta-3 adrenergic receptor
LigandBDBM50106823
Substrate/Competitorn/a
Meas. Tech.ChEBML_39052
Ki 20±n/a nM
Citation Washburn WNSher PMPoss KMGirotra RNMcCann PJGavai AVMikkilineni ABMathur ACheng PDejneka TCSun CQWang TCHarper TWRussell ADSlusarchyk DASkwish SAllen GTHillyer DEFrohlich BHAbboa-Offei BECap MWaldron TLGeorge RJTesfamariam BCiosek CPRyono DYoung DADickinson KESeymour AAArbeeny CMGregg RE Beta 3 agonists. Part 1: evolution from inception to BMS-194449. Bioorg Med Chem Lett 11:3035-9 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Beta-3 adrenergic receptor
Name:Beta-2 adrenergic receptor and beta-3 adrenergic receptor
Synonyms:ADRB3 | B3AR | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:43534.88
Organism:Homo sapiens (Human)
Description:n/a
Residue:408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50106823
n/a
NameBDBM50106823
Synonyms:CHEMBL102222 | N-(5-{(R)-2-[1,1-Bis-(4-methoxy-phenyl)-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-phenyl)-methanesulfonamide
TypeSmall organic molecule
Emp. Form.C25H30N2O6S
Mol. Mass.486.581
SMILESCOc1ccc(cc1)C(C)(NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1)c1ccc(OC)cc1
Structure
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