Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50098097 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_63795 |
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IC50 | 120±n/a nM |
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Citation | Macdonald, SJ; Dowle, MD; Harrison, LA; Shah, P; Johnson, MR; Inglis, GG; Clarke, GD; Smith, RA; Humphreys, D; Molloy, CR; Amour, A; Dixon, M; Murkitt, G; Godward, RE; Padfield, T; Skarzynski, T; Singh, OM; Kumar, KA; Fleetwood, G; Hodgson, ST; Hardy, GW; Finch, H The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate. Bioorg Med Chem Lett11:895-8 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50098097 |
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n/a |
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Name | BDBM50098097 |
Synonyms: | (3R,3aS,6aR)-1-Methanesulfonyl-5-(3-piperidin-1-yl-propionyl)-3-propyl-hexahydro-pyrrolo[3,4-b]pyrrol-2-one; hydrochloride | CHEMBL558365 |
Type | Small organic molecule |
Emp. Form. | C18H31N3O4S |
Mol. Mass. | 385.521 |
SMILES | CCC[C@@H]1[C@H]2CN(C[C@@H]2N(C1=O)S(C)(=O)=O)C(=O)CCN1CCCCC1 |
Structure |
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