| Reaction Details |
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 | Report a problem with these data |
| Target | Tubulin beta-2B chain |
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| Ligand | BDBM50109343 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_211170 |
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| Ki | 630±n/a nM |
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| Citation |  Li, Q; Woods, KW; Claiborne, A; Gwaltney, SL; Barr, KJ; Liu, G; Gehrke, L; Credo, RB; Hui, YH; Lee, J; Warner, RB; Kovar, P; Nukkala, MA; Zielinski, NA; Tahir, SK; Fitzgerald, M; Kim, KH; Marsh, K; Frost, D; Ng, SC; Rosenberg, S; Sham, HL Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent. Bioorg Med Chem Lett12:465-9 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tubulin beta-2B chain |
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| Name: | Tubulin beta-2B chain |
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| Synonyms: | TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49932.38 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_211651 |
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| Residue: | 445 |
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| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
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| BDBM50109343 |
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| n/a |
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| Name | BDBM50109343 |
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| Synonyms: | 1-Methyl-5-[(S)-5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazol-2-yl]-1H-indole | A-289099 | CHEMBL143850 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22N2O4 |
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| Mol. Mass. | 366.4104 |
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| SMILES | COc1cc(cc(OC)c1OC)[C@H]1CN=C(O1)c1ccc2n(C)ccc2c1 |c:15| |
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| Structure | 
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