| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-secretase 1 |
|---|
| Ligand | BDBM50137678 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_41388 (CHEMBL653510) |
|---|
| IC50 | 28±n/a nM |
|---|
| Citation |  Lamar, J; Hu, J; Bueno, AB; Yang, HC; Guo, D; Copp, JD; McGee, J; Gitter, B; Timm, D; May, P; McCarthy, J; Chen, SH Phe*-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SAR. Bioorg Med Chem Lett14:239-43 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-secretase 1 |
|---|
| Name: | Beta-secretase 1 |
|---|
| Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55755.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P56817 |
|---|
| Residue: | 501 |
|---|
| Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
|
|
|
|---|
| BDBM50137678 |
|---|
| n/a |
|---|
| Name | BDBM50137678 |
|---|
| Synonyms: | CHEMBL312277 | [(S)-1-((S)-1-{(3S,4S)-1-Benzyl-4-[(R)-1-((S)-benzylcarbamoyl)-2-methyl-propylcarbamoyl]-2-hydroxy-pentylcarbamoyl}-3-methylsulfanyl-propylcarbamoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C40H61N5O7S |
|---|
| Mol. Mass. | 756.007 |
|---|
| SMILES | CSCC[C@H](NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
