| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Angiotensin-converting enzyme |
|---|
| Ligand | BDBM50018792 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_34791 (CHEMBL643768) |
|---|
| IC50 | 200±n/a nM |
|---|
| Citation |  Smith, EM; Swiss, GF; Neustadt, BR; Gold, EH; Sommer, JA; Brown, AD; Chiu, PJ; Moran, R; Sybertz, EJ; Baum, T Synthesis and pharmacological activity of angiotensin converting enzyme inhibitors: N-(mercaptoacyl)-4-substituted-(S)-prolines. J Med Chem31:875-85 (1988) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Angiotensin-converting enzyme |
|---|
| Name: | Angiotensin-converting enzyme |
|---|
| Synonyms: | 3.2.1.- | 3.4.15.1 | ACE | ACE_RABIT | Angiotensin-converting enzyme, soluble form | CD_antigen=CD143 | DCP1 | Dipeptidyl carboxypeptidase I | Kininase II |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 150405.15 |
|---|
| Organism: | Oryctolagus cuniculus |
|---|
| Description: | n/a |
|---|
| Residue: | 1310 |
|---|
| Sequence: | MGAAPGRRGPRLLRPPPPLLLLLLLLRPPPAALTLDPGLLPGDFAADEAGARLFASSYNS
SAEQVLFRSTAASWAHDTNITAENARRQEEEALLSQEFAEAWGKKAKELYDPVWQNFTDP
ELRRIIGAVRTLGPANLPLAKRQQYNSLLSNMSQIYSTGKVCFPNKTASCWSLDPDLNNI
LASSRSYAMLLFAWEGWHNAVGIPLKPLYQEFTALSNEAYRQDGFSDTGAYWRSWYDSPT
FEEDLERIYHQLEPLYLNLHAYVRRVLHRRYGDRYINLRGPIPAHLLGNMWAQSWESIYD
MVVPFPDKPNLDVTSTMVQKGWNATHMFRVAEEFFTSLGLLPMPPEFWAESMLEKPEDGR
EVVCHASAWDFYNRKDFRIKQCTQVTMDQLSTVHHEMGHVQYYLQYKDQPVSLRRANPGF
HEAIGDVLALSVSTPAHLHKIGLLDHVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRW
GVFSGRTPSSRYNFDWWYLRTKYQGICPPVVRNETHFDAGAKFHIPSVTPYIRYFVSFVL
QFQFHQALCMEAGHQGPLHQCDIYQSTRAGAKLRAVLQAGCSRPWQEVLKDMVASDALDA
QPLLDYFQPVTQWLQEQNERNGEVLGWPEYQWRPPLPNNYPEGIDLVTDEAEASRFVEEY
DRSFQAVWNEYAEANWNYNTNITTEASKILLQKNMQIANHTLTYGNWARRFDVSNFQNAT
SKRIIKKVQDLQRAVLPVKELEEYNQILLDMETIYSVANVCRVDGSCLQLEPDLTNLMAT
SRKYDELLWVWTSWRDKVGRAILPYFPKYVEFTNKAARLNGYVDAGDSWRSMYETPTLEQ
DLERLFQELQPLYLNLHAYVGRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVA
PFPSASTMDATEAMIKQGWTPRRMFEEADKFFISLGLLPVPPEFWNKSMLEKPTDGREVV
CHASAWDFYNGKDFRIKQCTTVNMEDLVVVHHEMGHIQYFMQYKDLPVALREGANPGFHE
AIGDVLALSVSTPKHLHSINLLSSEGGGYEHDINFLMKMALDKIAFIPFSYLVDEWRWRV
FDGSITKENYNQEWWSLRLKYQGLCPPAPRSQGDFDPGAKFHIPSSVPYIRYFVSFIIQF
QFHEALCKAAGHTGPLHTCDIYQSKEAGKRLADAMKLGYSKPWPEAMKVITGQPNMSASA
MMNYFKPLMDWLLTENGRHGEKLGWPQYTWTPNSARSEGSLPDSGRVNFLGMNLDAQQAR
VGQWVLLFLGVALLLASLGLTQRLFSIRYQSLRQPHHGPQFGSEVELRHS
|
|
|
|---|
| BDBM50018792 |
|---|
| n/a |
|---|
| Name | BDBM50018792 |
|---|
| Synonyms: | (L)-1-(3-Mercapto-propionyl)-pyrrolidine-2-carboxylic acid | (S)-1-(3-mercaptopropanoyl)pyrrolidine-2-carboxylic acid | 1-(3-Mercapto-propionyl)-pyrrolidine-2-carboxylic acid | 1-(3-Mercapto-propionyl)-pyrrolidine-2-carboxylic acid(Captopril analogue) | CHEMBL10962 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C8H13NO3S |
|---|
| Mol. Mass. | 203.259 |
|---|
| SMILES | OC(=O)[C@@H]1CCCN1C(=O)CCS |r| |
|---|
| Structure | 
|
|---|
Search and Browse
