Ki Summary

Reaction Details

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Target

Platelet-activating factor receptor

Ligand

BDBM50004633

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_155148 (CHEMBL760189)

IC50

4.3±n/a nM

Citation

Fray, MJ; Bull, DJ; Cooper, K; Parry, MJ; Stefaniak, MH Novel antagonists of platelet-activating factor. 2. Synthesis and structure-activity relationships of potent and long-acting heterofused [1,5]benzodiazepine and [1,4]diazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine. J Med Chem38:3524-35 (1995) [PubMed]

More Info.:

Get all data from this article, Assay Method

Platelet-activating factor receptor

Name:

Platelet-activating factor receptor

Synonyms:

PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor

Type:

Protein

Mol. Mass.:

39005.63

Organism:

Cavia porcellus

Description:

n/a

Residue:

342

Sequence:

MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLT
VADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVK
YPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKG
SKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAV
FVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN

BDBM50004633

n/a

Name

BDBM50004633

Synonyms:

(S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester | 4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester | 4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-nicotinic acid ethyl ester | CHEMBL29067 | UK-74505

Type

Small organic molecule

Emp. Form.

C34H29ClN6O3

Mol. Mass.

605.085

SMILES

CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7|

Structure