Reaction Details |
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Target | Neprilysin |
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Ligand | BDBM50051785 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_144459 (CHEMBL755106) |
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IC50 | 1.6±n/a nM |
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Citation | Fournie-Zaluski, MC; Coric, P; Thery, V; Gonzalez, W; Meudal, H; Turcaud, S; Michel, JB; Roques, BP Design of orally active dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme with long duration of action. J Med Chem39:2594-608 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neprilysin |
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Name: | Neprilysin |
Synonyms: | Atriopeptidase | CD10 antigen | CD_antigen=CD10 | Enkephalinase | MME | NEP | NEP_RABIT | Neutral Endopeptidase | Neutral endopeptidase 24.11 |
Type: | Enzyme |
Mol. Mass.: | 85570.75 |
Organism: | Oryctolagus cuniculus (rabbit) |
Description: | NEP was purified to homogeneity from rabbit kidney. |
Residue: | 750 |
Sequence: | MGRSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTVIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCVNETAIDSRGGQPLLKLLPDVYGWPVATQNWEQTYGT
SWSAEKSIAQLNSNYGKKVLINFFVGTDDKNSMNHIIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMIAVAKLIRQEEGLPIDENQISVEMNKVMELEKEIANATTKSEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWSNFTNEIMSTVNINIPNEEDVVVYAPEYLIKLKPILT
KYFPRDFQNLFSWRFIMDLVSSLSRTYKDSRNAFRKALYGTTSESATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWITGAA
IVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGIDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GSLQNSVEFSEAFQCPKNSYMNPEKKCRVW
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BDBM50051785 |
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n/a |
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Name | BDBM50051785 |
Synonyms: | (2S,5R)-1-[2-((S)-2-Mercapto-3-phenyl-propionylamino)-acetyl]-5-phenyl-pyrrolidine-2-carboxylic acid | CHEMBL419499 | [(2S)-2-SULFANYL-3-PHENYLPROPANOYL]-GLY-(5-PHENYLPROLINE) |
Type | Small organic molecule |
Emp. Form. | C22H24N2O4S |
Mol. Mass. | 412.502 |
SMILES | OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccccc1)c1ccccc1 |
Structure |
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