| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuromedin-K receptor |
|---|
| Ligand | BDBM50050641 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_209396 (CHEMBL811328) |
|---|
| IC50 | 4±n/a nM |
|---|
| Citation |  Boden, P; Eden, JM; Hodgson, J; Horwell, DC; Hughes, J; McKnight, AT; Lewthwaite, RA; Pritchard, MC; Raphy, J; Meecham, K; Ratcliffe, GS; Suman-Chauhan, N; Woodruff, GN Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists. J Med Chem39:1664-75 (1996) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuromedin-K receptor |
|---|
| Name: | Neuromedin-K receptor |
|---|
| Synonyms: | NK3R_CAVPO | Neurokinin 3 receptor | Neurokinin NK3 | Neuromedin-K receptor | TACR3 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 49456.44 |
|---|
| Organism: | GUINEA PIG |
|---|
| Description: | Neurokinin NK3 TACR3 GUINEA PIG::P30098 |
|---|
| Residue: | 440 |
|---|
| Sequence: | MASPAGNLSAWPGWGWPPPAALRNLTSSPAPTASPSPAPSWTPSPRPGPAHPFLQPPWAV
ALWSLAYGAVVAVAVLGNLVVIWIVLAHKRMRTVTNSFLVNLAFADAAMAALNALVNFIY
ALHGEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATRIVIG
SIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGSRQHFTYHMIVIVLVYCFPLLIMGI
TYTIVGITLWGGEIPGDTCDKYQEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIY
QQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIHVSSYDEL
ELKATRLHPMRQSSLYTVTRMESMSVVFDSNDGDSARSSHQKRGTTRDVGSNVCSRRNSK
STSTTASFVSSSHMSVEEGS
|
|
|
|---|
| BDBM50050641 |
|---|
| n/a |
|---|
| Name | BDBM50050641 |
|---|
| Synonyms: | CHEMBL45340 | PD-161182 | [(R)-2-(2,3-Difluoro-phenyl)-1-methyl-1-(7-ureido-heptylcarbamoyl)-ethyl]-carbamic acid (S)-2-methyl-1-phenyl-propyl ester |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H40F2N4O4 |
|---|
| Mol. Mass. | 546.6491 |
|---|
| SMILES | CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
