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TargetKappa-type opioid receptor
LigandBDBM50369467
Substrate/Competitorn/a
Meas. Tech.ChEMBL_145851 (CHEMBL756114)
IC50 365±n/a nM
Citation Houghten, RA; Pinilla, C; Appel, JR; Blondelle, SE; Dooley, CT; Eichler, J; Nefzi, A; Ostresh, JM Mixture-based synthetic combinatorial libraries. J Med Chem42:3743-78 (1999) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Kappa-type opioid receptor
Name:Kappa-type opioid receptor
Synonyms:K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:42648.76
Organism:Homo sapiens (Human)
Description:P41145
Residue:380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
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  Blast E-value cutoff:
BDBM50369467
n/a
NameBDBM50369467
Synonyms:CHEMBL435414
TypeSmall organic molecule
Emp. Form.C25H43N3
Mol. Mass.385.629
SMILESCC1CCC(CN2[C@H](CN3[C@H](CN=C23)C2CCCCC2)C2CCCCC2)CC1 |wD:7.22,10.15,t:12,(-.93,-15.5,;-.32,-14.08,;1.22,-13.92,;1.84,-12.51,;.94,-11.27,;1.56,-9.86,;.66,-8.62,;1.12,-7.16,;-.09,-6.26,;-1.34,-7.16,;-2.87,-7.16,;-3.36,-8.6,;-2.11,-9.51,;-.87,-8.62,;-3.71,-5.86,;-5.24,-5.95,;-6.06,-4.65,;-5.36,-3.28,;-3.83,-3.21,;-3,-4.51,;2.59,-6.69,;3.72,-7.74,;5.19,-7.27,;5.53,-5.76,;4.39,-4.72,;2.91,-5.19,;-.6,-11.43,;-1.22,-12.83,)|
Structure
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