| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamyl aminopeptidase |
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| Ligand | BDBM50083375 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_32830 (CHEMBL873060) |
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| Ki | 51±n/a nM |
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| Citation |  David, C; Bischoff, L; Meudal, H; Mothé, A; De Mota, N; DaNascimento, S; Llorens-Cortes, C; Fournié-Zaluski, MC; Roques, BP Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme. J Med Chem42:5197-211 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamyl aminopeptidase |
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| Name: | Glutamyl aminopeptidase |
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| Synonyms: | AMPE_HUMAN | AP-A | Aminopeptidase A | CD_antigen=CD249 | Differentiation antigen gp160 | EAP | ENPEP | Glutamyl aminopeptidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 109226.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_32829 |
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| Residue: | 957 |
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| Sequence: | MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHL
PSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVS
ISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPS
SGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKK
ATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRI
SNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAME
NWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFAS
FFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYS
KGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTR
QMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSE
KEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLID
DAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYF
QGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPV
NLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLK
DTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFN
TELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG
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| BDBM50083375 |
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| n/a |
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| Name | BDBM50083375 |
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| Synonyms: | 3-[(1S,2R)-1-((S)-1,2-Dicarboxy-ethylcarbamoyl)-2-methyl-butylamino]-2-mercapto-1-(2-sulfamoyl-ethyl)-propyl-ammonium |
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| Type | Small organic molecule |
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| Emp. Form. | C15H31N4O7S2 |
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| Mol. Mass. | 443.559 |
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| SMILES | CC[C@@H](C)[C@H](NCC(S)C([NH3+])CCS(N)(=O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O |
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| Structure | 
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