| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1F |
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| Ligand | BDBM50005835 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2075 (CHEMBL875905) |
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| EC50 | 35±n/a nM |
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| Citation |  Xu, YC; Johnson, KW; Phebus, LA; Cohen, M; Nelson, DL; Schenck, K; Walker, CD; Fritz, JE; Kaldor, SW; LeTourneau, ME; Murff, RE; Zgombick, JM; Calligaro, DO; Audia, JE; Schaus, JM N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: a potent, selective, and orally active 5-HT(1F) receptor agonist potentially useful for migraine therapy. J Med Chem44:4031-4 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1F |
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| Name: | 5-hydroxytryptamine receptor 1F |
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| Synonyms: | 5-HT-1F | 5-HT1F | 5-hydroxytryptamine receptor 1F | 5HT1F_HUMAN | HTR1EL | HTR1F | Serotonin (5-HT) receptor | Serotonin 1f (5-HT1f) receptor | Serotonin receptor 1F |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41724.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | 5-HT1F HTR1F HUMAN::P30939 |
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| Residue: | 366 |
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| Sequence: | MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANY
LICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALD
RYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIV
STIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKS
VSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILG
AFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQK
LVRCRC
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|
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| BDBM50005835 |
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| n/a |
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| Name | BDBM50005835 |
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| Synonyms: | (3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide | 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide | 1-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide | 3-(2-(dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide | 3-[2-(dimethylamino)ethyl]-N-methylindole-5-methanesulfonamide | CHEMBL128 | SUMATRIPTAN | Sumatran | Sumax |
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| Type | Small organic molecule |
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| Emp. Form. | C14H21N3O2S |
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| Mol. Mass. | 295.4 |
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| SMILES | CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1 |
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| Structure | 
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