Reaction Details |
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Target | Nitric oxide synthase, inducible |
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Ligand | BDBM50063300 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_89494 (CHEMBL696859) |
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IC50 | 4900±n/a nM |
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Citation | Hallinan, EA; Hagen, TJ; Bergmanis, A; Moore, WM; Jerome, GM; Spangler, DP; Stevens, AM; Shieh, HS; Manning, PT; Pitzele, BS 5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors. J Med Chem47:900-6 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nitric oxide synthase, inducible |
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Name: | Nitric oxide synthase, inducible |
Synonyms: | HEP-NOS | Hepatocyte NOS | Inducible NO synthase | Inducible NOS | NOS type II | NOS2 | NOS2A | NOS2_HUMAN | Nitric oxide synthase, inducible (iNOS) | iNOS |
Type: | Homodimer |
Mol. Mass.: | 131141.95 |
Organism: | Homo sapiens (Human) |
Description: | P35228 |
Residue: | 1153 |
Sequence: | MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPL
VETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIM
TPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ
LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNI
RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG
RFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG
GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINI
AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEM
LNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT
ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPG
NGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGD
ELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDL
SKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQ
PALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQ
LLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL
PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCF
VRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPD
EDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLY
VCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDR
VAVQPSSLEMSAL
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BDBM50063300 |
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n/a |
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Name | BDBM50063300 |
Synonyms: | (L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino-2-amino-hexanoic acid | 6-Acetimidoylamino-2-amino-hexanoic acid | CHEMBL1744034 | CHEMBL7889 | L-N6-(1-iminoethyl)lysine | N~6~-[(1Z)-ethanimidoyl]-L-lysine | l-NIL |
Type | Small organic molecule |
Emp. Form. | C8H17N3O2 |
Mol. Mass. | 187.2395 |
SMILES | CC(N)=NCCCC[C@H](N)C(O)=O |r,w:3.3| |
Structure |
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