Found 979 hits with Last Name = 'hagen' and Initial = 'tj' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50049413
(CHEMBL3313945 | US11401286, Example 52)Show InChI InChI=1S/C19H16ClN5/c1-2-17-23-18(14-4-3-5-15(20)12-14)25-19(24-17)22-16-8-6-13(7-9-16)10-11-21/h3-9,12H,2,10H2,1H3,(H,22,23,24,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4D |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM50437324
(CHEMBL2407597)Show InChI InChI=1S/C14H12BrNO4S/c1-9-2-5-11(6-3-9)21(19,20)16-13-7-4-10(15)8-12(13)14(17)18/h2-8,16H,1H3,(H,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 2 |
ACS Med Chem Lett 4: (2013)
Article DOI: 10.1021/ml400034m BindingDB Entry DOI: 10.7270/Q2XW4M72 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50525013
(CHEMBL4476440 | US11401286, Example 81)Show InChI InChI=1S/C20H21ClN4O/c1-2-18-23-19(15-6-3-7-16(21)13-15)25-20(24-18)22-17-10-8-14(9-11-17)5-4-12-26/h3,6-11,13,26H,2,4-5,12H2,1H3,(H,22,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50049407
(CHEMBL3315271 | US11401286, Example 51)Show InChI InChI=1S/C18H14ClN5/c1-2-16-22-17(13-4-3-5-14(19)10-13)24-18(23-16)21-15-8-6-12(11-20)7-9-15/h3-10H,2H2,1H3,(H,21,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4B |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50049407
(CHEMBL3315271 | US11401286, Example 51)Show InChI InChI=1S/C18H14ClN5/c1-2-16-22-17(13-4-3-5-14(19)10-13)24-18(23-16)21-15-8-6-12(11-20)7-9-15/h3-10H,2H2,1H3,(H,21,22,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4D |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50049410
(CHEMBL3315265 | US11401286, Example 41)Show SMILES OC(=O)c1ccc(Nc2nc(nc(n2)-c2cccc(Cl)c2)C2CC2)cc1 Show InChI InChI=1S/C19H15ClN4O2/c20-14-3-1-2-13(10-14)17-22-16(11-4-5-11)23-19(24-17)21-15-8-6-12(7-9-15)18(25)26/h1-3,6-11H,4-5H2,(H,25,26)(H,21,22,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4D |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50524997
(CHEMBL4570605 | US11401286, Example 58)Show InChI InChI=1S/C19H19ClN4O/c1-2-17-22-18(14-4-3-5-15(20)12-14)24-19(23-17)21-16-8-6-13(7-9-16)10-11-25/h3-9,12,25H,2,10-11H2,1H3,(H,21,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50248919
((S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsu...)Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)N1C(=O)c2cccc(NC(C)=O)c2C1=O |r| Show InChI InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50248919
((S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsu...)Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)N1C(=O)c2cccc(NC(C)=O)c2C1=O |r| Show InChI InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4D2 expressed in baculovirus infected Sf9 insect cells using cAMP as substrate preincubated for 5 to 1... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50525005
(CHEMBL4459298 | US11401286, Example 171)Show SMILES CCc1cc(Nc2ccc(CC(N)=O)cc2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C20H19ClN4O/c1-2-16-12-19(23-17-8-6-13(7-9-17)10-18(22)26)25-20(24-16)14-4-3-5-15(21)11-14/h3-9,11-12H,2,10H2,1H3,(H2,22,26)(H,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50524998
(CHEMBL4564798 | US11401286, Example 62)Show SMILES CCc1nc(Nc2ccc(cc2)C(N)=O)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H16ClN5O/c1-2-15-22-17(12-4-3-5-13(19)10-12)24-18(23-15)21-14-8-6-11(7-9-14)16(20)25/h3-10H,2H2,1H3,(H2,20,25)(H,21,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50049410
(CHEMBL3315265 | US11401286, Example 41)Show SMILES OC(=O)c1ccc(Nc2nc(nc(n2)-c2cccc(Cl)c2)C2CC2)cc1 Show InChI InChI=1S/C19H15ClN4O2/c20-14-3-1-2-13(10-14)17-22-16(11-4-5-11)23-19(24-17)21-15-8-6-12(7-9-15)18(25)26/h1-3,6-11H,4-5H2,(H,25,26)(H,21,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4B |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50524991
(CHEMBL4544243 | US11401286, Example 57)Show SMILES CCc1nc(Nc2ccc(CC(N)=O)cc2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C19H18ClN5O/c1-2-17-23-18(13-4-3-5-14(20)11-13)25-19(24-17)22-15-8-6-12(7-9-15)10-16(21)26/h3-9,11H,2,10H2,1H3,(H2,21,26)(H,22,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50346121
(2-(4-(2-(5-chlorothiophen-2-yl)-5-ethyl-6-methylpy...)Show SMILES CCc1c(C)nc(nc1Nc1ccc(CC(O)=O)cc1)-c1ccc(Cl)s1 Show InChI InChI=1S/C19H18ClN3O2S/c1-3-14-11(2)21-19(15-8-9-16(20)26-15)23-18(14)22-13-6-4-12(5-7-13)10-17(24)25/h4-9H,3,10H2,1-2H3,(H,24,25)(H,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4B1 |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)Show InChI InChI=1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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DrugBank MCE PC cid PC sid PDB UniChem
Similars
| DrugBank Article PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 2 |
ACS Med Chem Lett 4: (2013)
Article DOI: 10.1021/ml400034m BindingDB Entry DOI: 10.7270/Q2XW4M72 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM76305
(5-chloranylquinolin-8-ol | 5-chloro-8-quinolinol |...)Show InChI InChI=1S/C9H6ClNO/c10-7-3-4-8(12)9-6(7)2-1-5-11-9/h1-5,12H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of recombinant full length human N-terminal GST/His6-tagged methionine aminopeptidase 2 expressed in baculovirus infected sf9 cells using ... |
Bioorg Med Chem 25: 813-824 (2017)
Article DOI: 10.1016/j.bmc.2016.11.013 BindingDB Entry DOI: 10.7270/Q2125VV2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50525009
(CHEMBL4437670 | US11401286, Example 191)Show InChI InChI=1S/C20H20ClN3O/c1-2-17-13-19(22-18-8-6-14(7-9-18)10-11-25)24-20(23-17)15-4-3-5-16(21)12-15/h3-9,12-13,25H,2,10-11H2,1H3,(H,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50525003
(CHEMBL4449185 | US11401286, Example 182)Show InChI InChI=1S/C20H19ClN2O2/c1-2-17-13-19(25-18-8-6-14(7-9-18)10-11-24)23-20(22-17)15-4-3-5-16(21)12-15/h3-9,12-13,24H,2,10-11H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, brain
(Homo sapiens (Human)) | BDBM50062142
(4,6-Dimethyl-piperidin-(2Z)-ylideneamine | CHEMBL2...)Show InChI InChI=1S/C7H14N2/c1-5-3-6(2)9-7(8)4-5/h5-6H,3-4H2,1-2H3,(H2,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
G. D. Searle Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human Neuronal nitric oxide synthase |
J Med Chem 41: 96-101 (1998)
Article DOI: 10.1021/jm9705059 BindingDB Entry DOI: 10.7270/Q2GM86D2 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50049416
(CHEMBL3315273)Show SMILES CCc1nc(Nc2ccc(Cc3nnn[nH]3)cc2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C19H17ClN8/c1-2-16-22-18(13-4-3-5-14(20)11-13)24-19(23-16)21-15-8-6-12(7-9-15)10-17-25-27-28-26-17/h3-9,11H,2,10H2,1H3,(H,21,22,23,24)(H,25,26,27,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4D |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50049416
(CHEMBL3315273)Show SMILES CCc1nc(Nc2ccc(Cc3nnn[nH]3)cc2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C19H17ClN8/c1-2-16-22-18(13-4-3-5-14(20)11-13)24-19(23-16)21-15-8-6-12(7-9-15)10-17-25-27-28-26-17/h3-9,11H,2,10H2,1H3,(H,21,22,23,24)(H,25,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4B |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, inducible
(Homo sapiens (Human)) | BDBM50062142
(4,6-Dimethyl-piperidin-(2Z)-ylideneamine | CHEMBL2...)Show InChI InChI=1S/C7H14N2/c1-5-3-6(2)9-7(8)4-5/h5-6H,3-4H2,1-2H3,(H2,8,9) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
G. D. Searle Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human Inducible nitric oxide synthase |
J Med Chem 41: 96-101 (1998)
Article DOI: 10.1021/jm9705059 BindingDB Entry DOI: 10.7270/Q2GM86D2 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50049418
(CHEMBL3315275 | US11401286, Example 59)Show SMILES CCc1nc(Nc2ccc(cc2)C(C)C(O)=O)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C20H19ClN4O2/c1-3-17-23-18(14-5-4-6-15(21)11-14)25-20(24-17)22-16-9-7-13(8-10-16)12(2)19(26)27/h4-12H,3H2,1-2H3,(H,26,27)(H,22,23,24,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4D |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50525000
(CHEMBL4561428 | US11401286, Example 120)Show SMILES CNC(=O)Cc1ccc(Nc2cc(nc3CCCc23)-c2cccc(Cl)c2)cc1 Show InChI InChI=1S/C23H22ClN3O/c1-25-23(28)12-15-8-10-18(11-9-15)26-22-14-21(16-4-2-5-17(24)13-16)27-20-7-3-6-19(20)22/h2,4-5,8-11,13-14H,3,6-7,12H2,1H3,(H,25,28)(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, inducible
(Homo sapiens (Human)) | BDBM50062133
(4-Methyl-piperidin-(2E)-ylideneamine | 4-Methyl-pi...)Show InChI InChI=1S/C6H12N2/c1-5-2-3-8-6(7)4-5/h5H,2-4H2,1H3,(H2,7,8) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
G. D. Searle Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human Inducible nitric oxide synthase |
J Med Chem 41: 96-101 (1998)
Article DOI: 10.1021/jm9705059 BindingDB Entry DOI: 10.7270/Q2GM86D2 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50525006
(CHEMBL4434783 | US11401286, Example 80)Show InChI InChI=1S/C18H17ClN4O/c1-2-16-21-17(13-4-3-5-14(19)10-13)23-18(22-16)20-15-8-6-12(11-24)7-9-15/h3-10,24H,2,11H2,1H3,(H,20,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50049417
(CHEMBL3315272)Show SMILES CCc1nc(Nc2ccc(cc2)-c2nnn[nH]2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H15ClN8/c1-2-15-21-16(12-4-3-5-13(19)10-12)23-18(22-15)20-14-8-6-11(7-9-14)17-24-26-27-25-17/h3-10H,2H2,1H3,(H,20,21,22,23)(H,24,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4B |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50524994
(CHEMBL4541964 | US11401286, Example 142)Show SMILES OC(=O)Cc1ccc(Cc2cc(nc(c2)C(F)(F)F)-c2cccc(Cl)c2)cc1 Show InChI InChI=1S/C21H15ClF3NO2/c22-17-3-1-2-16(12-17)18-9-15(10-19(26-18)21(23,24)25)8-13-4-6-14(7-5-13)11-20(27)28/h1-7,9-10,12H,8,11H2,(H,27,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE KEGG PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 127 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4D2 expressed in baculovirus infected Sf9 insect cells using cAMP as substrate preincubated for 5 to 1... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50524995
(CHEMBL4593524 | US11401286, Example 195)Show SMILES CCc1cc(Cc2ccc(CC(=O)NCCO)cc2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C23H24ClN3O2/c1-2-20-15-21(27-23(26-20)18-4-3-5-19(24)14-18)12-16-6-8-17(9-7-16)13-22(29)25-10-11-28/h3-9,14-15,28H,2,10-13H2,1H3,(H,25,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 128 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50049417
(CHEMBL3315272)Show SMILES CCc1nc(Nc2ccc(cc2)-c2nnn[nH]2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H15ClN8/c1-2-15-21-16(12-4-3-5-13(19)10-12)23-18(22-15)20-14-8-6-11(7-9-14)17-24-26-27-25-17/h3-10H,2H2,1H3,(H,20,21,22,23)(H,24,25,26,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 132 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4D |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50049415
(CHEMBL3315267 | US11401286, Example 49)Show SMILES Clc1cccc(c1)C1=NC(NC2CCC(=O)NC2)=NC(N1)C1CC1 |c:19,t:8| Show InChI InChI=1S/C17H20ClN5O/c18-12-3-1-2-11(8-12)16-21-15(10-4-5-10)22-17(23-16)20-13-6-7-14(24)19-9-13/h1-3,8,10,13,15H,4-7,9H2,(H,19,24)(H2,20,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 135 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4B |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50049411
(CHEMBL3315266 | US11401286, Example 38)Show SMILES OC(=O)c1ccc(Nc2nc(nc(n2)-c2ccc(Cl)cc2)C2CC2)cc1 Show InChI InChI=1S/C19H15ClN4O2/c20-14-7-3-12(4-8-14)17-22-16(11-1-2-11)23-19(24-17)21-15-9-5-13(6-10-15)18(25)26/h3-11H,1-2H2,(H,25,26)(H,21,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 135 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4B |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50525004
(CHEMBL4553222 | US11401286, Example 3)Show SMILES NC(=O)Cc1ccc(Nc2cc(nc3CCCc23)-c2cccc(Cl)c2)cc1 Show InChI InChI=1S/C22H20ClN3O/c23-16-4-1-3-15(12-16)20-13-21(18-5-2-6-19(18)26-20)25-17-9-7-14(8-10-17)11-22(24)27/h1,3-4,7-10,12-13H,2,5-6,11H2,(H2,24,27)(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 136 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50525008
(CHEMBL4567525 | US11401286, Example 125)Show SMILES NC(=O)Cc1ccc(Cc2cc(nc3CCCc23)-c2cccc(Cl)c2)cc1 Show InChI InChI=1S/C23H21ClN2O/c24-19-4-1-3-17(13-19)22-14-18(20-5-2-6-21(20)26-22)11-15-7-9-16(10-8-15)12-23(25)27/h1,3-4,7-10,13-14H,2,5-6,11-12H2,(H2,25,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 137 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50049412
(CHEMBL3315274)Show SMILES CCc1nc(Nc2ccc(NS(N)(=O)=O)cc2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C17H17ClN6O2S/c1-2-15-21-16(11-4-3-5-12(18)10-11)23-17(22-15)20-13-6-8-14(9-7-13)24-27(19,25)26/h3-10,24H,2H2,1H3,(H2,19,25,26)(H,20,21,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4D |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50049413
(CHEMBL3313945 | US11401286, Example 52)Show InChI InChI=1S/C19H16ClN5/c1-2-17-23-18(14-4-3-5-15(20)12-14)25-19(24-17)22-16-8-6-13(7-9-16)10-11-21/h3-9,12H,2,10H2,1H3,(H,22,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 165 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4B |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50525011
(CHEMBL4569780 | US11401286, Example 119)Show SMILES NC(=O)CCc1ccc(Nc2cc(nc3CCCc23)-c2cccc(Cl)c2)cc1 Show InChI InChI=1S/C23H22ClN3O/c24-17-4-1-3-16(13-17)21-14-22(19-5-2-6-20(19)27-21)26-18-10-7-15(8-11-18)9-12-23(25)28/h1,3-4,7-8,10-11,13-14H,2,5-6,9,12H2,(H2,25,28)(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 166 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, inducible
(Homo sapiens (Human)) | BDBM50066778
(5-Ethyl-4-methyl-pyrrolidin-(2E)-ylideneamine; hyd...)Show InChI InChI=1S/C7H14N2/c1-3-6-5(2)4-7(8)9-6/h5-6H,3-4H2,1-2H3,(H2,8,9) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of cloned (from RNA) human inducible nitric oxide synthase (hiNOS) |
J Med Chem 41: 3675-83 (1998)
Article DOI: 10.1021/jm970840x BindingDB Entry DOI: 10.7270/Q2XP75MP |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, brain
(Homo sapiens (Human)) | BDBM50066778
(5-Ethyl-4-methyl-pyrrolidin-(2E)-ylideneamine; hyd...)Show InChI InChI=1S/C7H14N2/c1-3-6-5(2)4-7(8)9-6/h5-6H,3-4H2,1-2H3,(H2,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of cloned (from RNA) human Neuronal nitric oxide synthase |
J Med Chem 41: 3675-83 (1998)
Article DOI: 10.1021/jm970840x BindingDB Entry DOI: 10.7270/Q2XP75MP |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, inducible
(Homo sapiens (Human)) | BDBM50062132
(6-Propyl-piperidin-(2Z)-ylideneamine | CHEMBL6760)Show InChI InChI=1S/C8H16N2/c1-2-4-7-5-3-6-8(9)10-7/h7H,2-6H2,1H3,(H2,9,10) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
G. D. Searle Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human Inducible nitric oxide synthase |
J Med Chem 41: 96-101 (1998)
Article DOI: 10.1021/jm9705059 BindingDB Entry DOI: 10.7270/Q2GM86D2 |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, brain
(Homo sapiens (Human)) | BDBM50062133
(4-Methyl-piperidin-(2E)-ylideneamine | 4-Methyl-pi...)Show InChI InChI=1S/C6H12N2/c1-5-2-3-8-6(7)4-5/h5H,2-4H2,1H3,(H2,7,8) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
G. D. Searle Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human Neuronal nitric oxide synthase |
J Med Chem 41: 96-101 (1998)
Article DOI: 10.1021/jm9705059 BindingDB Entry DOI: 10.7270/Q2GM86D2 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50049253
(CHEMBL3315262 | US11401286, Example 28)Show InChI InChI=1S/C15H12ClFN4S/c1-2-13-19-14(11-7-8-12(16)22-11)21-15(20-13)18-10-5-3-9(17)4-6-10/h3-8H,2H2,1H3,(H,18,19,20,21) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 207 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4D |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50049408
(CHEMBL3315270 | US11401286, Example 40)Show SMILES CCc1nc(Nc2ccc(cc2)C(O)=O)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H15ClN4O2/c1-2-15-21-16(12-4-3-5-13(19)10-12)23-18(22-15)20-14-8-6-11(7-9-14)17(24)25/h3-10H,2H2,1H3,(H,24,25)(H,20,21,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 213 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4D |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50049406
(CHEMBL3315263 | US11401286, Example 29)Show SMILES CC(C)c1nc(Nc2ccc(cc2)C(O)=O)nc(n1)-c1ccc(Cl)s1 Show InChI InChI=1S/C17H15ClN4O2S/c1-9(2)14-20-15(12-7-8-13(18)25-12)22-17(21-14)19-11-5-3-10(4-6-11)16(23)24/h3-9H,1-2H3,(H,23,24)(H,19,20,21,22) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 219 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4D |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50049406
(CHEMBL3315263 | US11401286, Example 29)Show SMILES CC(C)c1nc(Nc2ccc(cc2)C(O)=O)nc(n1)-c1ccc(Cl)s1 Show InChI InChI=1S/C17H15ClN4O2S/c1-9(2)14-20-15(12-7-8-13(18)25-12)22-17(21-14)19-11-5-3-10(4-6-11)16(23)24/h3-9H,1-2H3,(H,23,24)(H,19,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4B |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50524996
(CHEMBL4573171 | US11401286, Example 65)Show SMILES CCc1cc(Cc2ccc(CC(N)=O)cc2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C21H20ClN3O/c1-2-18-13-19(10-14-6-8-15(9-7-14)11-20(23)26)25-21(24-18)16-4-3-5-17(22)12-16/h3-9,12-13H,2,10-11H2,1H3,(H2,23,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 225 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Nitric oxide synthase, inducible
(Homo sapiens (Human)) | BDBM50066775
(5-Pentyl-4-trifluoromethyl-pyrrolidin-(2E)-ylidene...)Show InChI InChI=1S/C10H17F3N2/c1-2-3-4-5-8-7(10(11,12)13)6-9(14)15-8/h7-8H,2-6H2,1H3,(H2,14,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of cloned (from RNA) human inducible nitric oxide synthase (hiNOS) |
J Med Chem 41: 3675-83 (1998)
Article DOI: 10.1021/jm970840x BindingDB Entry DOI: 10.7270/Q2XP75MP |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50049146
(CHEMBL3315251 | US11401286, Example 36)Show SMILES OC(=O)Cc1ccc(Nc2nc(nc(n2)-c2cccc(Cl)c2)C2CC2)cc1 Show InChI InChI=1S/C20H17ClN4O2/c21-15-3-1-2-14(11-15)19-23-18(13-6-7-13)24-20(25-19)22-16-8-4-12(5-9-16)10-17(26)27/h1-5,8-9,11,13H,6-7,10H2,(H,26,27)(H,22,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 237 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4B |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50049408
(CHEMBL3315270 | US11401286, Example 40)Show SMILES CCc1nc(Nc2ccc(cc2)C(O)=O)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H15ClN4O2/c1-2-15-21-16(12-4-3-5-13(19)10-12)23-18(22-15)20-14-8-6-11(7-9-14)17(24)25/h3-10H,2H2,1H3,(H,24,25)(H,20,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 241 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... |
J Med Chem 62: 4884-4901 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50049408
(CHEMBL3315270 | US11401286, Example 40)Show SMILES CCc1nc(Nc2ccc(cc2)C(O)=O)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H15ClN4O2/c1-2-15-21-16(12-4-3-5-13(19)10-12)23-18(22-15)20-14-8-6-11(7-9-14)17(24)25/h3-10H,2H2,1H3,(H,24,25)(H,20,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 241 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4B |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | |