| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine phosphorylase |
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| Ligand | BDBM50122766 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305483 (CHEMBL830274) |
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| IC50 | 24400±n/a nM |
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| Citation |  Reigan, P; Edwards, PN; Gbaj, A; Cole, C; Barry, ST; Page, KM; Ashton, SE; Luke, RW; Douglas, KT; Stratford, IJ; Jaffar, M; Bryce, RA; Freeman, S Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs. J Med Chem48:392-402 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine phosphorylase |
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| Name: | Thymidine phosphorylase |
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| Synonyms: | TYPH_ECOLI | TdRPase | Thymidine Phosphorylase (TP) | deoA | tpp | ttg |
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| Type: | Enzyme |
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| Mol. Mass.: | 47198.54 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 440 |
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| Sequence: | MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLT
MAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHT
GGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSI
PLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLT
DMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKL
QAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALG
MAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAA
IKLADKAPESTPTVYRRISE
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| BDBM50122766 |
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| n/a |
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| Name | BDBM50122766 |
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| Synonyms: | 5-Bromo-6-(2-nitro-imidazol-1-ylmethyl)-1H-pyrimidine-2,4-dione | CHEMBL63979 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H6BrN5O4 |
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| Mol. Mass. | 316.068 |
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| SMILES | [O-][N+](=O)c1nccn1Cc1[n-]c(=[OH+])[nH]c(=O)c1Br |
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| Structure | 
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