Reaction Details |
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Target | Reverse transcriptase/RNaseH |
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Ligand | BDBM50164638 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_302539 (CHEMBL875215) |
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Ki | 46±n/a nM |
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Citation | Boyle, NA; Rajwanshi, VK; Prhavc, M; Wang, G; Fagan, P; Chen, F; Ewing, GJ; Brooks, JL; Hurd, T; Leeds, JM; Bruice, TW; Cook, PD Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase. J Med Chem48:2695-700 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase/RNaseH |
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Name: | Reverse transcriptase/RNaseH |
Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
Type: | PROTEIN |
Mol. Mass.: | 65229.15 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_1473730 |
Residue: | 566 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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BDBM50164638 |
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n/a |
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Name | BDBM50164638 |
Synonyms: | 2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamma-(difluoromethylene)triphosphates derivative | CHEMBL191316 |
Type | Small organic molecule |
Emp. Form. | C11H15BF3N2O11P3 |
Mol. Mass. | 511.973 |
SMILES | [BH3-]P(=O)(OCC1OC(CC1F)n1cc(C)c(=O)[nH]c1=O)OP([O-])(=O)C(F)(F)P([O-])([O-])=O |
Structure |
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