Reaction Details |
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Target | 17-beta-hydroxysteroid dehydrogenase type 1 |
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Ligand | BDBM50370657 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_305984 (CHEMBL832971) |
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IC50 | 290±n/a nM |
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Citation | Lawrence, HR; Vicker, N; Allan, GM; Smith, A; Mahon, MF; Tutill, HJ; Purohit, A; Reed, MJ; Potter, BV Novel and potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors. J Med Chem48:2759-62 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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17-beta-hydroxysteroid dehydrogenase type 1 |
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Name: | 17-beta-hydroxysteroid dehydrogenase type 1 |
Synonyms: | 17-beta-HSD 1 | 17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1) | 17-beta-hydroxysteroid dehydrogenase type 1 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB1_HUMAN | E17KSR | E2DH | EDH17B1 | EDH17B2 | EDHB17 | Estradiol 17-beta-dehydrogenase 1 | Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1) | HSD17B1 | Placental 17-beta-hydroxysteroid dehydrogenase | SDR28C1 |
Type: | Enzyme |
Mol. Mass.: | 34945.13 |
Organism: | Homo sapiens (Human) |
Description: | P14061 |
Residue: | 328 |
Sequence: | MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV
RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH
LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV
FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG
GAGPGAEDEAGRGAVGDPELGDPPAAPQ
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BDBM50370657 |
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n/a |
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Name | BDBM50370657 |
Synonyms: | CHEMBL1627742 |
Type | Small organic molecule |
Emp. Form. | C27H32N2O4 |
Mol. Mass. | 448.554 |
SMILES | COc1cc2[C@H]3CC[C@@]4(C)[C@@H](CC(CC(=O)NCc5cccnc5)C4=O)[C@@H]3CCc2cc1O |
Structure |
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