Reaction Details |
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Target | Serine/threonine-protein kinase B-raf |
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Ligand | BDBM50077961 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_327805 (CHEMBL869914) |
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Kd | 8±n/a nM |
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Citation | Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett16:378-81 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase B-raf |
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Name: | Serine/threonine-protein kinase B-raf |
Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 84446.00 |
Organism: | Homo sapiens (Human) |
Description: | P15056 |
Residue: | 766 |
Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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BDBM50077961 |
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n/a |
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Name | BDBM50077961 |
Synonyms: | 3-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-phenol | 3-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol | CHEMBL304624 |
Type | Small organic molecule |
Emp. Form. | C20H15N3O |
Mol. Mass. | 313.3526 |
SMILES | Oc1cccc(c1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 |
Structure |
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