| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50195130 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_422136 (CHEMBL907072) |
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| IC50 | 55±n/a nM |
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| Citation |  Jones, P; Altamura, S; Chakravarty, PK; Cecchetti, O; De Francesco, R; Gallinari, P; Ingenito, R; Meinke, PT; Petrocchi, A; Rowley, M; Scarpelli, R; Serafini, S; Steinkühler, C A series of novel, potent, and selective histone deacetylase inhibitors. Bioorg Med Chem Lett16:5948-52 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50195130 |
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| n/a |
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| Name | BDBM50195130 |
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| Synonyms: | (S)-N-(1-(biphenyl-3-ylamino)-1,8-dioxononan-2-yl)thiazole-5-carboxamide | CHEMBL217650 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27N3O3S |
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| Mol. Mass. | 449.565 |
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| SMILES | CC(=O)CCCCC[C@H](NC(=O)c1cncs1)C(=O)Nc1cccc(c1)-c1ccccc1 |
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| Structure | 
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