Reaction Details |
| Report a problem with these data |
Target | Coagulation factor X |
---|
Ligand | BDBM50228911 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_461701 (CHEMBL927722) |
---|
Ki | 2.8±n/a nM |
---|
Citation | Varnes, JG; Wacker, DA; Pinto, DJ; Orwat, MJ; Theroff, JP; Wells, B; Galemo, RA; Luettgen, JM; Knabb, RM; Bai, S; He, K; Lam, PY; Wexler, RR Structure-activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors. Bioorg Med Chem Lett18:749-54 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Coagulation factor X |
---|
Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
|
|
|
BDBM50228911 |
---|
n/a |
---|
Name | BDBM50228911 |
Synonyms: | 1-[2-(3-amino-benzo[d]isoxazol-5-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-2-(3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-propan-1-one | CHEMBL269191 |
Type | Small organic molecule |
Emp. Form. | C27H20F4N4O4S |
Mol. Mass. | 572.531 |
SMILES | CC(C(=O)c1cc(nn1-c1ccc2onc(N)c2c1)C(F)(F)F)c1ccc(cc1F)-c1ccccc1S(C)(=O)=O |
Structure |
|