Ki Summary

Reaction Details

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Target

Gag-Pro polyprotein

Ligand

BDBM50371711

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_463999 (CHEMBL929986)

IC50

353±n/a nM

Citation

Nguyen, JT; Zhang, M; Kumada, HO; Itami, A; Nishiyama, K; Kimura, T; Cheng, M; Hayashi, Y; Kiso, Y Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors. Bioorg Med Chem Lett18:366-70 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gag-Pro polyprotein

Name:

Gag-Pro polyprotein

Synonyms:

Human T-cell leukemia virus type I protease | PRO_HTL1A | gag-pro | prt

Type:

PROTEIN

Mol. Mass.:

71577.03

Organism:

Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)

Description:

ChEMBL_303297

Residue:

651

Sequence:

MGQIFSRSASPIPRPPRGLAAHHWLNFLQAAYRLEPGPSSYDFHQLKKFLKIALETPARI
CPINYSLLASLLPKGYPGRVNEILHILIQTQAQIPSRPAPPPPSSPTHDPPDSDPQIPPP
YVEPTAPQVLPVMHPHGAPPNHRPWQMKDLQAIKQEVSQAAPGSPQFMQTIRLAVQQFDP
TAKDLQDLLQYLCSSLVASLHHQQLDSLISEAETRGITGYNPLAGPLRVQANNPQQQGLR
REYQQLWLAAFAALPGSAKDPSWASILQGLEEPYHAFVERLNIALDNGLPEGTPKDPILR
SLAYSNANKECQKLLQARGHTNSPLGDMLRACQTWTPKDKTKVLVVQPKKPPPNQPCFRC
GKAGHWSRDCTQPRPPPGPCPLCQDPTHWKRDCPRLKPTIPEPEPEEDALLLDLPADIPH
PKNLHRGGGLTSPPTLQQVLPNQDPASILPVIPLDPARRPVIKAQVDTQTSHPKTIEALL
DTGADMTVLPIALFSSNTPLKNTSVLGAGGQTQDHFKLTSLPVLIRLPFRTTPIVLTSCL
VDTKNNWAIIGRDALQQCQGVLYLPEAKRPPVILPIQAPAVLGLEHLPRPPEISQFPLNQ
NASRPCNTWSGRPWRQAISNPTPGQGITQYSQLKRPMEPGDSSTTCGPLTL

BDBM50371711

n/a

Name

BDBM50371711

Synonyms:

CHEMBL233649 | KNI-10127

Type

Small organic molecule

Emp. Form.

C38H60N8O9S2

Mol. Mass.

837.061

SMILES

CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H]1N(CSC1(C)C)C(=O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(C)C)C(C)C)C(N)=O

Structure