| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pro polyprotein |
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| Ligand | BDBM50242888 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_463999 (CHEMBL929986) |
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| IC50 | 107±n/a nM |
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| Citation |  Nguyen, JT; Zhang, M; Kumada, HO; Itami, A; Nishiyama, K; Kimura, T; Cheng, M; Hayashi, Y; Kiso, Y Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors. Bioorg Med Chem Lett18:366-70 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gag-Pro polyprotein |
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| Name: | Gag-Pro polyprotein |
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| Synonyms: | Human T-cell leukemia virus type I protease | PRO_HTL1A | gag-pro | prt |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71577.03 |
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| Organism: | Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) |
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| Description: | ChEMBL_303297 |
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| Residue: | 651 |
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| Sequence: | MGQIFSRSASPIPRPPRGLAAHHWLNFLQAAYRLEPGPSSYDFHQLKKFLKIALETPARI
CPINYSLLASLLPKGYPGRVNEILHILIQTQAQIPSRPAPPPPSSPTHDPPDSDPQIPPP
YVEPTAPQVLPVMHPHGAPPNHRPWQMKDLQAIKQEVSQAAPGSPQFMQTIRLAVQQFDP
TAKDLQDLLQYLCSSLVASLHHQQLDSLISEAETRGITGYNPLAGPLRVQANNPQQQGLR
REYQQLWLAAFAALPGSAKDPSWASILQGLEEPYHAFVERLNIALDNGLPEGTPKDPILR
SLAYSNANKECQKLLQARGHTNSPLGDMLRACQTWTPKDKTKVLVVQPKKPPPNQPCFRC
GKAGHWSRDCTQPRPPPGPCPLCQDPTHWKRDCPRLKPTIPEPEPEEDALLLDLPADIPH
PKNLHRGGGLTSPPTLQQVLPNQDPASILPVIPLDPARRPVIKAQVDTQTSHPKTIEALL
DTGADMTVLPIALFSSNTPLKNTSVLGAGGQTQDHFKLTSLPVLIRLPFRTTPIVLTSCL
VDTKNNWAIIGRDALQQCQGVLYLPEAKRPPVILPIQAPAVLGLEHLPRPPEISQFPLNQ
NASRPCNTWSGRPWRQAISNPTPGQGITQYSQLKRPMEPGDSSTTCGPLTL
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| BDBM50242888 |
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| n/a |
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| Name | BDBM50242888 |
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| Synonyms: | (R)-3-((2S,3S)-3-((S)-2-((S)-2-acetamido-2-phenylacetamido)-3,3-dimethylbutanamido)-2-hydroxy-4-phenylbutanoyl)-N-isobutyl-5,5-dimethylthiazolidine-4-carboxamide | (R)-N-Isobutyl-3-{{(2S,3S)-3-{(2S)-2-[(2S)-2-acetylamino-2-phenyl]acetylamino-3,3-dimethyl}butanoylamino-2-hydroxy-4-phenyl}}butanoyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide | CHEMBL446908 | KNI-10516 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H51N5O6S |
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| Mol. Mass. | 681.885 |
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| SMILES | CC(C)CNC(=O)[C@H]1N(CSC1(C)C)C(=O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(C)=O)c1ccccc1)C(C)(C)C |r| |
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| Structure | 
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