| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pro polyprotein |
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| Ligand | BDBM50371729 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_463999 (CHEMBL929986) |
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| IC50 | 152±n/a nM |
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| Citation |  Nguyen, JT; Zhang, M; Kumada, HO; Itami, A; Nishiyama, K; Kimura, T; Cheng, M; Hayashi, Y; Kiso, Y Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors. Bioorg Med Chem Lett18:366-70 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gag-Pro polyprotein |
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| Name: | Gag-Pro polyprotein |
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| Synonyms: | Human T-cell leukemia virus type I protease | PRO_HTL1A | gag-pro | prt |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71577.03 |
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| Organism: | Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) |
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| Description: | ChEMBL_303297 |
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| Residue: | 651 |
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| Sequence: | MGQIFSRSASPIPRPPRGLAAHHWLNFLQAAYRLEPGPSSYDFHQLKKFLKIALETPARI
CPINYSLLASLLPKGYPGRVNEILHILIQTQAQIPSRPAPPPPSSPTHDPPDSDPQIPPP
YVEPTAPQVLPVMHPHGAPPNHRPWQMKDLQAIKQEVSQAAPGSPQFMQTIRLAVQQFDP
TAKDLQDLLQYLCSSLVASLHHQQLDSLISEAETRGITGYNPLAGPLRVQANNPQQQGLR
REYQQLWLAAFAALPGSAKDPSWASILQGLEEPYHAFVERLNIALDNGLPEGTPKDPILR
SLAYSNANKECQKLLQARGHTNSPLGDMLRACQTWTPKDKTKVLVVQPKKPPPNQPCFRC
GKAGHWSRDCTQPRPPPGPCPLCQDPTHWKRDCPRLKPTIPEPEPEEDALLLDLPADIPH
PKNLHRGGGLTSPPTLQQVLPNQDPASILPVIPLDPARRPVIKAQVDTQTSHPKTIEALL
DTGADMTVLPIALFSSNTPLKNTSVLGAGGQTQDHFKLTSLPVLIRLPFRTTPIVLTSCL
VDTKNNWAIIGRDALQQCQGVLYLPEAKRPPVILPIQAPAVLGLEHLPRPPEISQFPLNQ
NASRPCNTWSGRPWRQAISNPTPGQGITQYSQLKRPMEPGDSSTTCGPLTL
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| BDBM50371729 |
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| n/a |
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| Name | BDBM50371729 |
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| Synonyms: | CHEMBL436816 |
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| Type | Small organic molecule |
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| Emp. Form. | C47H71N11O11S2 |
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| Mol. Mass. | 1030.264 |
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| SMILES | CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H]1N(CSC1(C)C)C(=O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1)C(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O |
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| Structure | 
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