Reaction Details |
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Target | Transcription factor p65 |
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Ligand | BDBM50372502 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_465172 (CHEMBL945842) |
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IC50 | 1000±n/a nM |
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Citation | Xie, Y; Deng, S; Thomas, CJ; Liu, Y; Zhang, YQ; Rinderspacher, A; Huang, W; Gong, G; Wyler, M; Cayanis, E; Aulner, N; Többen, U; Chung, C; Pampou, S; Southall, N; Vidovic, D; Schürer, S; Branden, L; Davis, RE; Staudt, LM; Inglese, J; Austin, CP; Landry, DW; Smith, DH; Auld, DS Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation. Bioorg Med Chem Lett18:329-35 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transcription factor p65 |
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Name: | Transcription factor p65 |
Synonyms: | NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1 |
Type: | Enzyme |
Mol. Mass.: | 60211.92 |
Organism: | Homo sapiens (Human) |
Description: | Q04206 |
Residue: | 551 |
Sequence: | MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT
IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQC
VKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLS
HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS
QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE
KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINY
DEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQA
VAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQ
GIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADM
DFSALLSQISS
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BDBM50372502 |
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n/a |
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Name | BDBM50372502 |
Synonyms: | CHEMBL256403 |
Type | Small organic molecule |
Emp. Form. | C14H11ClN2O2S2 |
Mol. Mass. | 338.832 |
SMILES | Cc1ccc2cccc(NS(=O)(=O)c3ccc(Cl)s3)c2n1 |
Structure |
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