Ki Summary

Reaction Details

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Target

NF-kappa-B inhibitor alpha

Ligand

BDBM60287

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_465171 (CHEMBL945841)

EC50

12000±n/a nM

Citation

Xie, Y; Deng, S; Thomas, CJ; Liu, Y; Zhang, YQ; Rinderspacher, A; Huang, W; Gong, G; Wyler, M; Cayanis, E; Aulner, N; Többen, U; Chung, C; Pampou, S; Southall, N; Vidovic, D; Schürer, S; Branden, L; Davis, RE; Staudt, LM; Inglese, J; Austin, CP; Landry, DW; Smith, DH; Auld, DS Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation. Bioorg Med Chem Lett18:329-35 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

NF-kappa-B inhibitor alpha

Name:

NF-kappa-B inhibitor alpha

Synonyms:

Type:

GST fusion protein

Mol. Mass.:

35584.84

Organism:

Homo sapiens (Human)

Description:

It was produced in E. coli as GST-tagged fusion protein (Santa Cruz Biotechnology).

Residue:

317

Sequence:

MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVP
RGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVI
TNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATN
YNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCG
ADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTE
DELPYDDCVFGGQRLTL

BDBM60287

n/a

Name

BDBM60287

Synonyms:

2-nitro-N-(8-quinolinyl)benzenesulfonamide | 2-nitro-N-(8-quinolyl)benzenesulfonamide | 2-nitro-N-quinolin-8-yl-benzenesulfonamide | 2-nitro-N-quinolin-8-ylbenzenesulfonamide | MLS001123640 | SMR000658615 | cid_739449

Type

Small organic molecule

Emp. Form.

C15H11N3O4S

Mol. Mass.

329.331

SMILES

[O-][N+](=O)c1ccccc1S(=O)(=O)Nc1cccc2cccnc12

Structure