Reaction Details |
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Target | NAD-dependent protein deacetylase sirtuin-2 |
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Ligand | BDBM50373747 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_468418 (CHEMBL934433) |
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IC50 | 19500±n/a nM |
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Citation | Neugebauer, RC; Uchiechowska, U; Meier, R; Hruby, H; Valkov, V; Verdin, E; Sippl, W; Jung, M Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. J Med Chem51:1203-13 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NAD-dependent protein deacetylase sirtuin-2 |
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Name: | NAD-dependent protein deacetylase sirtuin-2 |
Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) |
Type: | Hydrolase |
Mol. Mass.: | 43172.62 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 389 |
Sequence: | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
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BDBM50373747 |
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n/a |
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Name | BDBM50373747 |
Synonyms: | CHEMBL270905 |
Type | Small organic molecule |
Emp. Form. | C19H13IO2 |
Mol. Mass. | 400.2098 |
SMILES | Ic1ccc2c3C(CC(=O)Oc3ccc2c1)c1ccccc1 |w:6.18| |
Structure |
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