| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50373947 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_468802 (CHEMBL932042) |
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| IC50 | 3.6±n/a nM |
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| Citation |  Mader, M; de Dios, A; Shih, C; Bonjouklian, R; Li, T; White, W; López de Uralde, B; Sánchez-Martinez, C; del Prado, M; Jaramillo, C; de Diego, E; Martín Cabrejas, LM; Dominguez, C; Montero, C; Shepherd, T; Dally, R; Toth, JE; Chatterjee, A; Pleite, S; Blanco-Urgoiti, J; Perez, L; Barberis, M; Lorite, MJ; Jambrina, E; Nevill, CR; Lee, PA; Schultz, RC; Wolos, JA; Li, LC; Campbell, RM; Anderson, BD Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38alpha MAP kinase inhibitors with excellent in vivo antiinflammatory properties. Bioorg Med Chem Lett18:179-83 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50373947 |
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| n/a |
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| Name | BDBM50373947 |
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| Synonyms: | CHEMBL274201 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22Cl2FN5 |
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| Mol. Mass. | 494.391 |
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| SMILES | CC(C)(C)Cn1cnc2ccc(nc12)-c1nc([nH]c1-c1ccc(F)cc1)-c1c(Cl)cccc1Cl |
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| Structure | 
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