| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50373949 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_468804 (CHEMBL932044) |
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| IC50 | 34.3±n/a nM |
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| Citation |  Mader, M; de Dios, A; Shih, C; Bonjouklian, R; Li, T; White, W; López de Uralde, B; Sánchez-Martinez, C; del Prado, M; Jaramillo, C; de Diego, E; Martín Cabrejas, LM; Dominguez, C; Montero, C; Shepherd, T; Dally, R; Toth, JE; Chatterjee, A; Pleite, S; Blanco-Urgoiti, J; Perez, L; Barberis, M; Lorite, MJ; Jambrina, E; Nevill, CR; Lee, PA; Schultz, RC; Wolos, JA; Li, LC; Campbell, RM; Anderson, BD Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38alpha MAP kinase inhibitors with excellent in vivo antiinflammatory properties. Bioorg Med Chem Lett18:179-83 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | Crk1 | Csbp1 | Csbp2 | MAP Kinase p38 alpha | MAP kinase p38 | MK14_MOUSE | Mapk14 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 41281.22 |
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| Organism: | Mus musculus (mouse) |
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| Description: | The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.. Soluble murine p38R was extracted from cell pellets and purified using ion-exchange chromatography. |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50373949 |
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| n/a |
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| Name | BDBM50373949 |
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| Synonyms: | CHEMBL411291 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28FN5 |
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| Mol. Mass. | 405.511 |
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| SMILES | CC(C)(C)Cn1cnc2ccc(nc12)-c1nc([nH]c1-c1ccc(F)cc1)C(C)(C)C |
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| Structure | 
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