Ki Summary

Reaction Details

Report a problem with these data

Target

Tyrosine-protein kinase Lck

Ligand

BDBM50374618

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_469608 (CHEMBL934187)

IC50

12±n/a nM

Citation

Martin, MW; Newcomb, J; Nunes, JJ; Boucher, C; Chai, L; Epstein, LF; Faust, T; Flores, S; Gallant, P; Gore, A; Gu, Y; Hsieh, F; Huang, X; Kim, JL; Middleton, S; Morgenstern, K; Oliveira-dos-Santos, A; Patel, VF; Powers, D; Rose, P; Tudor, Y; Turci, SM; Welcher, AA; Zack, D; Zhao, H; Zhu, L; Zhu, X; Ghiron, C; Ermann, M; Johnston, D; Saluste, CG Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity. J Med Chem51:1637-48 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase Lck

Name:

Tyrosine-protein kinase Lck

Synonyms:

Type:

n/a

Mol. Mass.:

57987.83

Organism:

Homo sapiens (Human)

Description:

P06239

Residue:

509

Sequence:

MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP

BDBM50374618

n/a

Name

BDBM50374618

Synonyms:

CHEMBL408030

Type

Small organic molecule

Emp. Form.

C34H35N7O2

Mol. Mass.

573.6874

SMILES

Cc1cccc(C)c1-n1c2nc3ccccc3n2c2nc(Nc3ccc(OCCCN4CCCCC4)cc3)ncc2c1=O |(29.92,5.51,;31.26,4.75,;32.58,5.52,;33.93,4.74,;33.92,3.2,;32.59,2.44,;32.58,.9,;31.26,3.21,;29.93,2.44,;29.92,.9,;31.06,-.14,;30.43,-1.54,;31.05,-2.94,;30.15,-4.18,;28.61,-4.01,;28,-2.61,;28.91,-1.37,;28.59,.13,;27.25,.9,;25.91,.12,;24.58,.89,;23.25,.13,;21.92,.9,;21.93,2.44,;20.6,3.21,;19.26,2.44,;17.93,3.21,;16.59,2.44,;15.26,3.21,;15.26,4.75,;16.59,5.52,;17.93,4.74,;19.26,5.51,;19.27,7.05,;17.93,7.82,;16.59,7.05,;19.26,.89,;20.6,.13,;24.59,2.44,;25.91,3.21,;27.25,2.45,;28.58,3.22,;28.58,4.76,)|

Structure