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TargetMitogen-activated protein kinase 14
LigandBDBM50374622
Substrate/Competitorn/a
Meas. Tech.ChEMBL_469610 (CHEMBL934189)
IC50>10000±n/a nM
Citation Martin, MW; Newcomb, J; Nunes, JJ; Boucher, C; Chai, L; Epstein, LF; Faust, T; Flores, S; Gallant, P; Gore, A; Gu, Y; Hsieh, F; Huang, X; Kim, JL; Middleton, S; Morgenstern, K; Oliveira-dos-Santos, A; Patel, VF; Powers, D; Rose, P; Tudor, Y; Turci, SM; Welcher, AA; Zack, D; Zhao, H; Zhu, L; Zhu, X; Ghiron, C; Ermann, M; Johnston, D; Saluste, CG Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity. J Med Chem51:1637-48 (2008) [PubMed]  Article
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Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50374622
n/a
NameBDBM50374622
Synonyms:CHEMBL407279
TypeSmall organic molecule
Emp. Form.C34H36N8O3
Mol. Mass.604.7014
SMILESCOc1cc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)ccc1OCCN1CCN(C)CC1 |(21.28,-33.67,;19.94,-34.43,;19.94,-35.97,;21.27,-36.75,;21.26,-38.29,;22.59,-39.06,;23.92,-38.29,;23.93,-36.75,;25.25,-35.98,;26.59,-36.74,;26.59,-38.29,;25.26,-39.06,;27.93,-39.06,;28.25,-40.56,;27.34,-41.79,;27.96,-43.2,;29.49,-43.36,;30.39,-42.13,;29.78,-40.73,;30.41,-39.32,;29.27,-38.29,;29.27,-36.74,;30.6,-35.97,;30.6,-34.44,;29.26,-33.67,;31.93,-33.67,;33.27,-34.44,;33.26,-35.98,;31.93,-36.75,;31.92,-38.29,;27.93,-35.96,;27.93,-34.42,;19.94,-39.06,;18.6,-38.29,;18.6,-36.74,;17.27,-35.97,;15.93,-36.74,;14.6,-35.97,;14.6,-34.43,;15.92,-33.65,;15.91,-32.12,;14.58,-31.36,;14.57,-29.82,;13.25,-32.14,;13.26,-33.68,)|
Structure
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