| Reaction Details |
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 | Report a problem with these data |
| Target | Androgen receptor |
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| Ligand | BDBM50376214 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_475674 (CHEMBL937560) |
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| IC50 | 250±n/a nM |
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| Citation |  Bisson, WH; Cheltsov, AV; Bruey-Sedano, N; Lin, B; Chen, J; Goldberger, N; May, LT; Christopoulos, A; Dalton, JT; Sexton, PM; Zhang, XK; Abagyan, R Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs. Proc Natl Acad Sci U S A104:11927-32 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Androgen receptor |
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| Name: | Androgen receptor |
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| Synonyms: | ANDR_HUMAN | AR | Androgen Receptor | Androgen receptor (AR) | Androgen receptor/Baculoviral IAP repeat-containing protein 2 | DHTR | Dihydrotestosterone receptor | NR3C4 | Nuclear receptor subfamily 3 group C member 4 |
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| Type: | Receptor |
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| Mol. Mass.: | 99185.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | CHO cells were stably transfected with human AR gene.
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| Residue: | 920 |
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| Sequence: | MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQ
QQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQ
SALECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSAD
LKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELC
KAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAG
KSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQ
SRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAA
GPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGEAGAVAP
YGYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRL
ETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRN
DCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKL
TVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWA
KALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSR
MYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELD
RIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEII
SVQVPKILSGKVKPIYFHTQ
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| BDBM50376214 |
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| n/a |
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| Name | BDBM50376214 |
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| Synonyms: | CHEMBL263660 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H16F3NOS |
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| Mol. Mass. | 435.461 |
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| SMILES | FC(F)(F)c1ccc2Sc3ccccc3N(CC(=O)c3cccc4ccccc34)c2c1 |
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| Structure | 
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