Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM50376445 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_476693 (CHEMBL933483) |
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IC50 | 14±n/a nM |
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Citation | Wrobleski, ST; Lin, S; Hynes, J; Wu, H; Pitt, S; Shen, DR; Zhang, R; Gillooly, KM; Shuster, DJ; McIntyre, KW; Doweyko, AM; Kish, KF; Tredup, JA; Duke, GJ; Sack, JS; McKinnon, M; Dodd, J; Barrish, JC; Schieven, GL; Leftheris, K Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38 alpha MAP kinase inhibitors. Bioorg Med Chem Lett18:2739-44 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 41286.76 |
Organism: | Homo sapiens (Human) |
Description: | Q16539 |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50376445 |
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n/a |
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Name | BDBM50376445 |
Synonyms: | CHEMBL411257 |
Type | Small organic molecule |
Emp. Form. | C29H27N7O2 |
Mol. Mass. | 505.5704 |
SMILES | C[C@H](NC(=O)c1cn2ncnc(Nc3cc(NC(=O)c4ccncc4)ccc3C)c2c1C)c1ccccc1 |
Structure |
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