| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50259462 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_501175 (CHEMBL975288) |
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| IC50 | 2.9±n/a nM |
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| Citation |  Bezençon, O; Bur, D; Weller, T; Richard-Bildstein, S; Remen, L; Sifferlen, T; Corminboeuf, O; Grisostomi, C; Boss, C; Prade, L; Delahaye, S; Treiber, A; Strickner, P; Binkert, C; Hess, P; Steiner, B; Fischli, W Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors. J Med Chem52:3689-702 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50259462 |
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| n/a |
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| Name | BDBM50259462 |
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| Synonyms: | (rac)-(1RS,5SR)-7-(4-{[(2-Chloro-3,6-difluoro-benzyl)-methyl-amino]-methyl}-phenyl)-3,9-diaza-bicyclo[3.3.1]non-6-ene-6-carboxylic acid cyclopropyl-(3-methoxy-2-methyl-benzyl)-amide | CHEMBL451603 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H39ClF2N4O2 |
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| Mol. Mass. | 621.16 |
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| SMILES | COc1cccc(CN(C2CC2)C(=O)C2=C(CC3CNCC2N3)c2ccc(CN(C)Cc3c(F)ccc(F)c3Cl)cc2)c1C |t:15,TLB:23:15:22:19.20.18,THB:12:14:22:19.20.18| |
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| Structure | 
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