| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Ligand | BDBM50297910 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_584481 (CHEMBL1059160) |
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| IC50 | 2±n/a nM |
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| Citation |  Zhang, X; Zhou, Z; Yang, H; Chen, J; Feng, Y; Du, L; Leng, Y; Shen, J 4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice. Bioorg Med Chem Lett19:4455-8 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 32409.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28845 |
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| Residue: | 292 |
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| Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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| BDBM50297910 |
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| n/a |
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| Name | BDBM50297910 |
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| Synonyms: | 4-[(3-Chlorophenylsulfonamido)methyl]-N-cycloheptyl-N-propylbenzamide | CHEMBL551949 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31ClN2O3S |
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| Mol. Mass. | 463.033 |
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| SMILES | CCCN(C1CCCCCC1)C(=O)c1ccc(CNS(=O)(=O)c2cccc(Cl)c2)cc1 |
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| Structure | 
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