| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50317946 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_630913 (CHEMBL1113905) |
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| IC50 | 5±n/a nM |
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| Citation |  Bressi, JC; de Jong, R; Wu, Y; Jennings, AJ; Brown, JW; O'Connell, S; Tari, LW; Skene, RJ; Vu, P; Navre, M; Cao, X; Gangloff, AR Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity. Bioorg Med Chem Lett20:3138-41 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50317946 |
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| n/a |
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| Name | BDBM50317946 |
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| Synonyms: | CHEMBL1095451 | N-hydroxy-3-(3-(5-methyl-1-phenethyl-4-phenyl-1H-imidazol-2-yl)phenyl)acrylamide |
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| Type | Small organic molecule |
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| Emp. Form. | C27H25N3O2 |
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| Mol. Mass. | 423.5063 |
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| SMILES | Cc1c(nc(-c2cccc(\C=C\C(=O)NO)c2)n1CCc1ccccc1)-c1ccccc1 |
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| Structure | 
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