| Reaction Details |
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 | Report a problem with these data |
| Target | Steroid 11-beta-monooxygenase |
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| Ligand | BDBM50338360 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_728153 (CHEMBL1687154) |
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| IC50 | >1000±n/a nM |
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| Citation |  Kaku, T; Matsunaga, N; Ojida, A; Tanaka, T; Hara, T; Yamaoka, M; Kusaka, M; Tasaka, A 17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors. Bioorg Med Chem19:1751-70 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Steroid 11-beta-monooxygenase |
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| Name: | Steroid 11-beta-monooxygenase |
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| Synonyms: | Cytochrome P450c11B3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57146.22 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_728153 |
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| Residue: | 498 |
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| Sequence: | MALRVTADVWARPWQCLHRTRALGSTATQAPKTLKPFEAIPQYSRNKWLKMIQILREQGQ
ENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPRRMTLESWVAHRE
LRGLRRGVFLLNGADWRFNRLQLNPNMLSPKAVQSFVPFVDVVARDFVENLKKRMLENVH
GSMSMDIQSNVFNYTMEASHFVISGERLGLTGHDLNPESLKFIHALHSMFKSTTQLMFLP
KNLTRWTSTQVWKGHFESWDIISEYVTNVSRNVYRELAEGRQQSWSVISEMVAQSTLSMD
AIHANSMELIAGSVDTTAISLVMTLFELARNPDVQQALRQESLAAEASIAANPQKAMSDL
PLLRAALKETLRLYPIGSSLERIVDSDLVLQNYHVPAGTLVIIYLYSMGRNPAVFPRPER
YMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEVLLLLHHMLKIFQVETLRQEDVQMAY
RFVLMPNPRLVLTIRPVS
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| BDBM50338360 |
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| n/a |
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| Name | BDBM50338360 |
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| Synonyms: | (+)-(R)-7-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl)-2-methyl-1H-benzo[e]isoindol-3(2H)-one | CHEMBL1682905 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N3O2 |
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| Mol. Mass. | 335.3996 |
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| SMILES | CC(C)[C@](O)(c1cnc[nH]1)c1ccc2c3CN(C)C(=O)c3ccc2c1 |r| |
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| Structure | 
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