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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 14 | ||
| Ligand | BDBM50347936 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_756761 (CHEMBL1805307) | ||
| IC50 | 325±n/a nM | ||
| Citation |  Selness, SR; Devraj, RV; Devadas, B; Walker, JK; Boehm, TL; Durley, RC; Shieh, H; Xing, L; Rucker, PV; Jerome, KD; Benson, AG; Marrufo, LD; Madsen, HM; Hitchcock, J; Owen, TJ; Christie, L; Promo, MA; Hickory, BS; Alvira, E; Naing, W; Blevis-Bal, R; Messing, D; Yang, J; Mao, MK; Yalamanchili, G; Vonder Embse, R; Hirsch, J; Saabye, M; Bonar, S; Webb, E; Anderson, G; Monahan, JB Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. Bioorg Med Chem Lett21:4066-71 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 14 | |||
| Name: | Mitogen-activated protein kinase 14 | ||
| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 41286.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q16539 | ||
| Residue: | 360 | ||
| Sequence: |
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| BDBM50347936 | |||
| n/a | |||
| Name | BDBM50347936 | ||
| Synonyms: | CHEMBL1802640 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H19BrF2N2O4 | ||
| Mol. Mass. | 493.298 | ||
| SMILES | CNC(=O)c1ccc(CO)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(13.61,-21.01,;13.57,-19.47,;14.89,-18.67,;16.24,-19.41,;14.86,-17.13,;16.19,-16.36,;16.18,-14.81,;14.85,-14.05,;14.84,-12.51,;16.17,-11.73,;13.53,-14.83,;13.52,-16.37,;12.19,-14.06,;12.19,-12.51,;13.52,-11.73,;10.85,-11.74,;9.53,-12.51,;8.19,-11.74,;6.86,-12.52,;5.52,-11.75,;4.2,-12.52,;2.87,-11.75,;2.86,-10.21,;1.53,-9.44,;4.2,-9.43,;5.53,-10.2,;6.87,-9.44,;9.52,-14.06,;8.19,-14.83,;10.86,-14.83,;10.86,-16.37,)| | ||
| Structure | 
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