Reaction Details |
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Target | Sphingosine 1-phosphate receptor 1 |
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Ligand | BDBM50419963 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_809729 (CHEMBL2016148) |
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EC50 | 1.26±n/a nM |
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Citation | Xu, H; Zhang, H; Luan, L; Xu, Y; Li, C; Wang, Y; Han, F; Yang, T; Ren, F; Xiang, JN; Elliott, JD; Zhao, Y; Guo, TB; Lu, H; Zhang, W; Hirst, D; Lindon, M; Lin, X Discovery of thiadiazole amides as potent, S1P3-sparing agonists of sphingosine-1-phosphate 1 (S1P1) receptor. Bioorg Med Chem Lett22:2456-9 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sphingosine 1-phosphate receptor 1 |
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Name: | Sphingosine 1-phosphate receptor 1 |
Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
Type: | Enzyme |
Mol. Mass.: | 42836.02 |
Organism: | Homo sapiens (Human) |
Description: | P21453 |
Residue: | 382 |
Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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BDBM50419963 |
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n/a |
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Name | BDBM50419963 |
Synonyms: | CHEMBL2011736 |
Type | Small organic molecule |
Emp. Form. | C23H23F3N4O5S2 |
Mol. Mass. | 556.578 |
SMILES | CCCCN(C(=O)c1ccc(cc1)C(F)(F)F)c1nnc(s1)-c1ccc(cc1)S(=O)(=O)NCCC(O)=O |
Structure |
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