Ki Summary

Reaction Details

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Target

Free fatty acid receptor 1

Ligand

BDBM50382521

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_816331 (CHEMBL2027153)

130±n/a nM

Citation

Negoro, N; Sasaki, S; Ito, M; Kitamura, S; Tsujihata, Y; Ito, R; Suzuki, M; Takeuchi, K; Suzuki, N; Miyazaki, J; Santou, T; Odani, T; Kanzaki, N; Funami, M; Tanaka, T; Yasuma, T; Momose, Y Identification of fused-ring alkanoic acids with improved pharmacokinetic profiles that act as G protein-coupled receptor 40/free fatty acid receptor 1 agonists. J Med Chem55:1538-52 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Free fatty acid receptor 1

Name:

Free fatty acid receptor 1

Synonyms:

FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

31473.32

Organism:

Homo sapiens (Human)

Description:

O14842

Residue:

300

Sequence:

MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLP
LKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRP
CYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAG
PARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPY
NASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK

BDBM50382521

n/a

Name

BDBM50382521

Synonyms:

CHEMBL2022255

Type

Small organic molecule

Emp. Form.

C26H26O5

Mol. Mass.

418.4816

SMILES

COc1ccc(COc2ccc3C(CC(O)=O)COc3c2)cc1-c1c(C)cccc1C |(11.32,-39.26,;11.33,-40.8,;12.67,-41.55,;13.99,-40.78,;15.34,-41.54,;15.34,-43.08,;16.68,-43.85,;18.01,-43.07,;19.35,-43.84,;19.35,-45.38,;20.68,-46.15,;22.02,-45.36,;23.48,-45.83,;23.97,-47.29,;25.48,-47.6,;25.97,-49.06,;26.5,-46.45,;24.38,-44.58,;23.47,-43.34,;22.01,-43.82,;20.67,-43.06,;14.01,-43.86,;12.68,-43.09,;11.36,-43.86,;10.02,-43.09,;10.01,-41.55,;8.69,-43.86,;8.69,-45.41,;10.04,-46.17,;11.36,-45.39,;12.7,-46.15,)|

Structure