| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 1 |
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| Ligand | BDBM50420025 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_819767 (CHEMBL2034279) |
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| EC50 | 63.1±n/a nM |
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| Citation |  Deng, G; Meng, Q; Liu, Q; Xu, X; Xu, Q; Ren, F; Guo, TB; Lu, H; Xiang, JN; Elliott, JD; Lin, X Identification of benzoxazole analogs as novel, S1P(3) sparing S1P(1) agonists. Bioorg Med Chem Lett22:3973-7 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 1 |
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| Name: | Sphingosine 1-phosphate receptor 1 |
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| Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42836.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21453 |
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| Residue: | 382 |
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| Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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| BDBM50420025 |
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| n/a |
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| Name | BDBM50420025 |
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| Synonyms: | CHEMBL2032317 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21F3N2O2S |
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| Mol. Mass. | 458.496 |
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| SMILES | OC(=O)CCCCCc1cn2cc(nc2s1)-c1ccc(-c2ccccc2)c(c1)C(F)(F)F |
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| Structure | 
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