Reaction Details |
| Report a problem with these data |
Target | Aurora kinase B |
---|
Ligand | BDBM50384170 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_820049 (CHEMBL2032822) |
---|
IC50 | 4±n/a nM |
---|
Citation | Le Brazidec, JY; Pasis, A; Tam, B; Boykin, C; Wang, D; Marcotte, DJ; Claassen, G; Chong, JH; Chao, J; Fan, J; Nguyen, K; Silvian, L; Ling, L; Zhang, L; Choi, M; Teng, M; Pathan, N; Zhao, S; Li, T; Taveras, A Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors. Bioorg Med Chem Lett22:4033-7 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Aurora kinase B |
---|
Name: | Aurora kinase B |
Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
Type: | Protein |
Mol. Mass.: | 39327.72 |
Organism: | Homo sapiens (Human) |
Description: | Q96GD4 |
Residue: | 344 |
Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
|
|
|
BDBM50384170 |
---|
n/a |
---|
Name | BDBM50384170 |
Synonyms: | CHEMBL2029913 |
Type | Small organic molecule |
Emp. Form. | C26H33N9O |
Mol. Mass. | 487.5999 |
SMILES | CN1CCN(CC1)C(=O)c1cc(Nc2ncc3cc(-c4ccnn4C)n(C4CCCC4)c3n2)cn1C |
Structure |
|